Erciyes University Medical School, Department of Endocrinology and Metabolism, Kayseri, Turkey.
Erciyes University Medical School, Department of Endocrinology and Metabolism, Kayseri, Turkey.
Best Pract Res Clin Endocrinol Metab. 2017 Feb;31(1):3-11. doi: 10.1016/j.beem.2017.02.001. Epub 2017 Feb 23.
Growth hormone deficiency (GHD) can develop due to a variety of conditions, and may occur either as isolated or multiple pituitary hormone deficiencies. It has been previously demonstrated that GH is one of the most frequent hormonal deficiencies in adult patients with hypopituitarism. The most frequent classical causes of adult-onset GHD (AO-GHD) are pituitary adenomas and/or their treatment. However, during the last decade an increasing number of studies from different parts of the world have revealed that non-tumoural causes of hypopituitarism are more common than previously known. Therefore, in this review our aim is to briefly summarize the classical and non-classical acquired causes of GHD in adults.
生长激素缺乏症（GHD）可由多种情况引起，可能表现为孤立性或多种垂体激素缺乏。先前的研究表明，GH 是垂体功能减退症成年患者中最常见的激素缺乏症之一。成人发病的 GHD（AO-GHD）最常见的经典原因是垂体腺瘤和/或其治疗。然而，在过去十年中，来自世界不同地区的越来越多的研究表明，与以前已知的相比，垂体功能减退的非肿瘤原因更为常见。因此，在这篇综述中，我们的目的是简要总结成人 GHD 的经典和非经典获得性病因。
