Sjöström Anna, Chisalita Simona I, Höybye Charlotte
Department of Clinical Chemistry, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.
J Clin Med. 2022 Sep 20;11(19):5510. doi: 10.3390/jcm11195510.
Growth hormone (GH) changes body composition, including increasing body water. GH is known to have an anti-natriuretic effect in the kidney, but little is known of its effect on arginine-vasopressin (AVP) release. We studied the effect of GH on AVP release by measurement of copeptin, a fragment from the same precursor protein, in GH-treated patients with GH deficiency. The study was designed as a retrospective cohort study of biobank samples from 34 patients substituted with GH between 1999 and 2004. Copeptin and insulin-like growth factor 1 (IGF-1) results were compared with previously obtained data. An increase in IGF-1 and copeptin was seen at 3 and 6 months’ treatment compared to baseline. Between the 3 and 6 months follow up, copeptin levels were stable. There was a difference in HbA1c between 3 and 6 months (p < 0.01) and between baseline and 6 months (p = 0.042), with higher levels at 6 months. In addition, LDL levels were lower at the 6 months follow up (p = 0.046). The waist circumference at 3 months was lower (p = 0.02). To conclude, three months of GH treatment increased the levels of copeptin and the increase remained at 6 months. This could be a compensatory mechanism balancing the anti-natriuretic effect of GH treatment seen in previous studies.
生长激素（GH）可改变身体成分，包括增加机体水分。已知GH在肾脏具有抗利尿钠作用，但其对精氨酸加压素（AVP）释放的影响却鲜为人知。我们通过测量copeptin（一种来自同一前体蛋白的片段）来研究GH对GH缺乏症患者AVP释放的影响，这些患者接受了GH治疗。本研究设计为一项回顾性队列研究，研究对象为1999年至2004年间接受GH替代治疗的34例患者的生物样本库样本。将copeptin和胰岛素样生长因子1（IGF-1）的结果与先前获得的数据进行比较。与基线相比，治疗3个月和6个月时IGF-1和copeptin水平升高。在3个月至6个月的随访期间，copeptin水平稳定。3个月和6个月时糖化血红蛋白（HbA1c）存在差异（p<0.01），基线和6个月时也存在差异（p=0.042），6个月时水平更高。此外，6个月随访时低密度脂蛋白（LDL）水平较低（p=0.046）。3个月时腰围较低（p=0.02）。总之，3个月的GH治疗可提高copeptin水平，且在6个月时仍保持升高。这可能是一种补偿机制，可平衡先前研究中所见的GH治疗的抗利尿钠作用。
