Compton Leigh A, Doyle Leona A
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Surg Pathol Clin. 2017 Jun;10(2):299-317. doi: 10.1016/j.path.2017.01.005. Epub 2017 Mar 18.
Cutaneous mesenchymal neoplasms often pose significant diagnostic challenges; many such entities are rare or show clinical and histologic overlap with both other mesenchymal and non-mesenchymal lesions. Recent advances in the genetic classification of many cutaneous mesenchymal neoplasms have not only helped define unique pathologic entities and increase our understanding of their biology, but have also provided new diagnostic markers. This review details these recent discoveries, with a focus on their implications for tumor classification and diagnosis.
皮肤间质性肿瘤常常带来重大的诊断挑战；许多这类实体肿瘤较为罕见，或在临床及组织学上与其他间质性和非间质性病变存在重叠。许多皮肤间质性肿瘤在基因分类方面的最新进展不仅有助于明确独特的病理实体，增进我们对其生物学特性的理解，还提供了新的诊断标志物。本综述详细阐述了这些最新发现，重点关注它们对肿瘤分类和诊断的意义。
