Department of Pathology, Treviso General Hospital, Piazza Ospedale,1 31100 Treviso, Italy.
Semin Diagn Pathol. 2013 Nov;30(4):375-81. doi: 10.1053/j.semdp.2013.11.003. Epub 2013 Nov 12.
Soft tissue sarcomas represent an heterogenous group of malignancies. They represent a diagnostic challenge, and their accurate classification impact over treatment options. Sarcomas, similarly to hematologic neoplasm, often harbor relatively specific genetic aberrations, the recognition of which can be used to improved diagnostic accuracy. This review will focus on the clinical relevance of molecular analysis in soft tissue sarcomas, trying to elucidate its role as a diagnostic tool as well as a potential prognostic/predictive marker.
软组织肉瘤是一组异质性恶性肿瘤。它们构成了诊断上的挑战，其准确分类影响着治疗方案的选择。与血液系统肿瘤类似，肉瘤通常存在相对特异的遗传学异常，这些异常的识别有助于提高诊断的准确性。本文将重点讨论分子分析在软组织肉瘤中的临床意义，试图阐明其作为诊断工具以及潜在预后/预测标志物的作用。
