Patel Pratik B, Kuan Edward C, Peng Kevin A, Yoo Frederick, Nelson Scott D, Abemayor Elliot
Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Am J Otolaryngol. 2017 Jul-Aug;38(4):475-478. doi: 10.1016/j.amjoto.2017.04.013. Epub 2017 Apr 21.
Angiosarcoma of the tongue is an exceedingly rare malignancy of the head and neck. Such lesions can be primary in nature or occur in a previously irradiated field. We examine a series of cases with relation to clinical presentation, diagnosis, management, and outcomes.
Retrospective chart review of all patients with angiosarcoma of the tongue at a tertiary academic institution yielded a single case between 2005 and 2016. The MEDLINE database was additionally searched for all case series or reports of angiosarcoma arising in the tongue, and pertinent clinical data were extracted.
The clinical presentation, disease course, and management of a patient with angiosarcoma of the tongue are presented. Institutional and literature search yielded a total of eight patients with angiosarcoma of the tongue. The most common primary sites were dorsal and lateral oral tongue. Treatment consisted of surgical resection in 63% of cases with adjuvant therapy administered in 75% of cases. Follow-up times varied per patient, but 63% had persistent or recurrent disease and 67% died of or with disease within two years of index presentation.
Angiosarcoma of the tongue is a rare and highly aggressive tumor, accounting for fewer than 1% of all head and neck malignancies. The mainstay of treatment is surgical resection with negative margins followed by adjuvant chemoradiation for high-risk features. Due to rarity of the disease, consensus on optimal treatment approach is lacking, and multi-center prospective studies would be helpful to set clinical guidelines.
舌血管肉瘤是一种极为罕见的头颈部恶性肿瘤。此类病变可为原发性，也可发生于既往接受过放疗的区域。我们研究了一系列病例的临床表现、诊断、治疗及预后情况。
对一所三级学术机构中所有舌血管肉瘤患者进行回顾性病历审查，2005年至2016年间仅有1例病例。此外，检索MEDLINE数据库中所有关于舌部血管肉瘤的病例系列或报告，并提取相关临床数据。
介绍了1例舌血管肉瘤患者的临床表现、病程及治疗情况。机构研究和文献检索共纳入8例舌血管肉瘤患者。最常见的原发部位是舌背和舌侧缘。63%的病例接受了手术切除，75%的病例接受了辅助治疗。每位患者的随访时间各不相同，但63%的患者疾病持续或复发，67%的患者在初次就诊后两年内死于该疾病或伴有该疾病。
舌血管肉瘤是一种罕见且侵袭性很强的肿瘤，占所有头颈部恶性肿瘤的比例不到1%。治疗的主要方法是手术切除，切缘阴性，对于具有高危特征的患者随后进行辅助放化疗。由于该疾病罕见，缺乏关于最佳治疗方法的共识，多中心前瞻性研究将有助于制定临床指南。
