Eapen Alex K, de Cock Peter, Crincoli Christine M, Means Charlotte, Wismer Tina, Pappas Christopher
Cargill, Inc., Wayzata, MN, USA.
Cargill R&D Centre Europe, Vilvoorde, Belgium.
Food Chem Toxicol. 2017 Jul;105:448-455. doi: 10.1016/j.fct.2017.04.049. Epub 2017 May 4.
Polyols, also known as sugar alcohols, are widely used in the formulation of tooth-friendly and reduced-calorie foods. Considering the significant health benefits of polyols in products formulated for human use, there is increased interest in evaluating potential uses in companion animal applications. Erythritol and xylitol are two polyols which are currently widely used in products ranging from reduced-sugar foods to personal care and cosmetics. Published studies have shown that both of these compounds are well-tolerated in rodents. Their toxicity profiles differ when comparing canine safety data. Doses of xylitol as low as 0.15 g/kg-BW in dogs can result in life-threatening hypoglycemia and acute liver failure, whereas erythritol is well-tolerated in dogs with reported No Adverse Effect Levels upwards of 5 g/kg-BW/day in repeat-dose studies. While pivotal studies substantiating the safe use of erythritol in humans have been published, there are limited published studies to support the safe use of erythritol in dogs. Here we present the results of an acute oral and a sub-chronic oral toxicity study in Beagle dogs. Given the potential health benefits of oral products formulated with erythritol and the data presented herein substantiating the safe use in dogs, erythritol can be safely used in products for canines.
多元醇，也被称为糖醇，广泛用于生产对牙齿有益且低热量的食品。鉴于多元醇在人类用产品中具有显著的健康益处，人们对评估其在伴侣动物应用中的潜在用途的兴趣日益增加。赤藓糖醇和木糖醇是两种目前广泛用于从低糖食品到个人护理和化妆品等各类产品的多元醇。已发表的研究表明，这两种化合物在啮齿动物中耐受性良好。然而，对比犬类安全数据时，它们的毒性特征有所不同。犬类摄入低至0.15克/千克体重的木糖醇会导致危及生命的低血糖和急性肝衰竭，而在重复剂量研究中，赤藓糖醇在犬类中的耐受性良好，据报道无不良反应水平高达5克/千克体重/天。虽然已发表了证实赤藓糖醇在人类中安全使用的关键研究，但支持赤藓糖醇在犬类中安全使用的已发表研究有限。在此，我们展示了比格犬急性口服和亚慢性口服毒性研究的结果。鉴于用赤藓糖醇配制的口服产品具有潜在的健康益处，且本文提供的数据证实了其在犬类中的安全使用，赤藓糖醇可安全用于犬类产品。
