Shimizu Mamu, Miyawaki Shingo, Kuroda Taishin, Umeta Miyu, Kawabe Mifumi, Watanabe Kazuhiro
Laboratory of Veterinary Surgery, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Heliyon. 2022 Aug 13;8(8):e10224. doi: 10.1016/j.heliyon.2022.e10224. eCollection 2022 Aug.
Periodontal disease (PD) is the most common oral disease that is caused by infection with periodontal-disease-associated bacteria (PDAB) such as and in dogs as well as in humans. Unlike humans, most dogs do not follow daily oral hygiene routine, and this results in many dogs being affected by PD. Thus, to prevent PD, it is important to control PDAB. Xylitol is a sugar alcohol that inhibits the growth of oral bacteria in humans. However, xylitol is poisonous to dogs and can lead to hypoglycemia and hepatic failure. Herein, we show the inhibitory effect of erythritol, a sugar alcohol that can be used safely in dogs, on the growth of PDAB isolated from dogs with PD. Oral bacteria were isolated from the oral cavities of dogs with PD, and the distribution of PDAB was evaluated. Interestingly, , a bacterium typically responsible for PD in humans, was not isolated from dog samples. The bacteriostatic effect of erythritol supplementation was investigated on isolated PDAB . Our results show that erythritol exert bacteriostatic effects on PDAB comparable to xylitol. Thus, application of erythritol can be suggested to control PDAB in dogs in the future.
牙周病（PD）是由牙周病相关细菌（PDAB）感染引起的最常见的口腔疾病，在犬类和人类中均有发生，如 和 。与人类不同，大多数犬类不遵循日常口腔卫生习惯，这导致许多犬类受到牙周病的影响。因此，为预防牙周病，控制牙周病相关细菌很重要。木糖醇是一种能抑制人类口腔细菌生长的糖醇。然而，木糖醇对犬类有毒，可导致低血糖和肝衰竭。在此，我们展示了赤藓糖醇（一种可安全用于犬类的糖醇）对从患有牙周病的犬类中分离出的牙周病相关细菌生长的抑制作用。从患有牙周病的犬类口腔中分离出口腔细菌，并评估牙周病相关细菌的分布。有趣的是，未从犬类样本中分离出通常导致人类牙周病的 菌。研究了补充赤藓糖醇对分离出的牙周病相关细菌的抑菌作用。我们的结果表明，赤藓糖醇对牙周病相关细菌的抑菌作用与木糖醇相当。因此，未来可以建议应用赤藓糖醇来控制犬类中的牙周病相关细菌。
