Peck Ammon B, Nguyen Cuong Q
Department of Pathology and Infectious Diseases, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA; Center for Orphan Autoimmune Disorders, College of Dentistry, University of Florida, Gainesville, FL 32608, USA.
Department of Pathology and Infectious Diseases, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA; Center for Orphan Autoimmune Disorders, College of Dentistry, University of Florida, Gainesville, FL 32608, USA; Department of Oral Biology, College of Dentistry, University of Florida, FL 32608, USA.
Clin Immunol. 2017 Sep;182:14-23. doi: 10.1016/j.clim.2017.05.001. Epub 2017 May 3.
For decades, Sjögren's syndrome (SS) and Sjögren's syndrome-like (SS-like) disease in patients and mouse models, respectively, have been intensely investigated in attempts to identify the underlying etiologies, the pathophysiological changes defining disease phenotypes, the nature of the autoimmune responses, and the propensity for developing B cell lymphomas. An emerging question is whether the generation of a multitude of mouse models and the data obtained from their studies is actually important to the understanding of the human disease and potential interventional therapies. In this brief report, we comment on how and why mouse models can stimulate interest in specific lines of research that apparently parallel aspects of human SS. Focusing on two mouse models, NOD and B6·Il14α, we present the possible relevance of mouse models to human SS, highlighting a few selected disease-associated biological processes that have baffled both SS and SS-like investigations for decades.
几十年来，人们分别对患者和小鼠模型中的干燥综合征（SS）及类干燥综合征（SS样）疾病进行了深入研究，试图确定潜在病因、定义疾病表型的病理生理变化、自身免疫反应的性质以及发生B细胞淋巴瘤的倾向。一个新出现的问题是，众多小鼠模型的建立以及从这些研究中获得的数据对于理解人类疾病和潜在的干预疗法是否真的重要。在这份简短的报告中，我们评论了小鼠模型如何以及为何能够激发对某些特定研究方向的兴趣，这些研究方向显然与人类SS的某些方面相似。聚焦于两种小鼠模型，即NOD和B6·Il14α，我们阐述了小鼠模型与人类SS的可能相关性，突出了一些经过挑选的与疾病相关的生物学过程，这些过程几十年来一直困扰着SS和SS样疾病的研究。
