B淋巴细胞在干燥综合征中的多重作用。
Multiple Roles for B-Lymphocytes in Sjogren's Syndrome.
作者信息
Ambrus Julian Lawrence, Suresh Lakshmanan, Peck Ammon
机构信息
Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, 100 High Street, Buffalo, NY 14203, USA.
Immco Diagnostics and the Department of Oral Diagnostic Sciences, SUNY at Buffalo School of Dental Science, Buffalo, NY 14203, USA.
出版信息
J Clin Med. 2016 Oct 8;5(10):87. doi: 10.3390/jcm5100087.
Abstract
Sjogren's syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell-directed therapies in the management of patients with SS.
摘要
干燥综合征（SS）是一种复杂的异质性自身免疫性疾病，可导致唾液腺和泪腺功能丧失，可能包括淋巴瘤等多种全身表现。多种细胞类型参与疾病的发病机制。本文综述了干燥综合征患者B细胞亚群异常的证据、B细胞在干燥综合征中的关键作用以及B细胞导向疗法在干燥综合征患者管理中的现状。
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