质子泵抑制剂的使用通过调节血脑屏障药物转运引发肝硬化患者的脑病。 - Suppr

Proton Pump Inhibitor Administration Triggers Encephalopathy in Cirrhotic Patients by Modulating Blood-Brain Barrier Drug Transport.

作者信息

Assaraf Julie, Weiss Nicolas, Thabut Dominique

机构信息

Unité de Soins Intensifs d'Hépato-gastroentérologie, Groupement Hospitalier Pitié-Salpêtrière-Charles Foix, Paris, France.

Brain Liver Pitié-Salpêtrière Study Group and Unité de Réanimation Neurologique, Fédération de Neurologie, Pôle des Maladies du Système Nerveux, Groupement Hospitalier Pitié-Salpêtrière-Charles Foix, Paris, France.

出版信息

Gastroenterology. 2017 Jun;152(8):2077. doi: 10.1053/j.gastro.2016.10.049. Epub 2017 May 4.

DOI:10.1053/j.gastro.2016.10.049

PMID:28478148

Abstract

摘要

相似文献

Proton Pump Inhibitor Administration Triggers Encephalopathy in Cirrhotic Patients by Modulating Blood-Brain Barrier Drug Transport.质子泵抑制剂的使用通过调节血脑屏障药物转运引发肝硬化患者的脑病。

Gastroenterology. 2017 Jun;152(8):2077. doi: 10.1053/j.gastro.2016.10.049. Epub 2017 May 4.

Modification in CSF specific gravity in acutely decompensated cirrhosis and acute on chronic liver failure independent of encephalopathy, evidences for an early blood-CSF barrier dysfunction in cirrhosis.急性失代偿期肝硬化和慢性肝功能衰竭急性发作时脑脊液比重的改变与肝性脑病无关，提示肝硬化早期血脑屏障功能障碍。

Metab Brain Dis. 2017 Apr;32(2):369-376. doi: 10.1007/s11011-016-9916-9. Epub 2016 Oct 11.

Proton Pump Inhibitors and the Possible Development of Hepatic Encephalopathy in Cirrhotic Patients: True Association or Residual Confounding?质子泵抑制剂与肝硬化患者肝性脑病的可能发生：真实关联还是残余混杂？

Gastroenterology. 2017 Jun;152(8):2076. doi: 10.1053/j.gastro.2016.10.050. Epub 2017 May 4.

Are proton pump inhibitors a threat for spontaneous bacterial peritonitis and hepatic encephalopathy in cirrhosis? Not so fast.质子泵抑制剂对肝硬化患者的自发性细菌性腹膜炎和肝性脑病构成威胁吗？别急着下结论。

Hepatology. 2017 Jan;65(1):393. doi: 10.1002/hep.28858. Epub 2016 Nov 15.

Letter to the Editor: Proton Pump Inhibitors Are Associated With Minimal and Overt Hepatic Encephalopathy and Increased Mortality in Patients With Cirrhosis.致编辑的信：质子泵抑制剂与肝硬化患者的轻微及显性肝性脑病相关，并增加死亡率。

Hepatology. 2019 Aug;70(2):760-761. doi: 10.1002/hep.30641.

Association of proton pump inhibitors with the risk of hepatic encephalopathy during hospitalization for liver cirrhosis.质子泵抑制剂与肝硬化住院期间肝性脑病风险的关联

United European Gastroenterol J. 2018 Oct;6(8):1179-1187. doi: 10.1177/2050640618773564. Epub 2018 Apr 23.

Letter to the Editor: Proton Pump Inhibitors in Cirrhosis: A Marker of Morbid Conditions or a Cause of Mortality?致编辑的信：肝硬化中的质子泵抑制剂：病态状况的标志物还是死亡原因？

Hepatology. 2019 Aug;70(2):761-762. doi: 10.1002/hep.30642.

[Not Available].[无可用内容]。

MMW Fortschr Med. 2017 Jun;159(12):36. doi: 10.1007/s15006-017-9840-x.

Evaluation of cognitivity, proinflammatory cytokines, and brain magnetic resonance imaging in minimal hepatic encephalopathy induced by cirrhosis and extrahepatic portal vein obstruction.肝硬化和肝外门静脉阻塞所致轻微肝性脑病的认知功能、促炎细胞因子及脑磁共振成像评估

J Gastroenterol Hepatol. 2016 Dec;31(12):1986-1994. doi: 10.1111/jgh.13427.

Results of meta-analysis should be treated critically.荟萃分析的结果应持批判态度。

World J Gastroenterol. 2020 Mar 7;26(9):992-994. doi: 10.3748/wjg.v26.i9.992.

引用本文的文献

TIPS and hepatic encephalopathy in patients with cirrhosis.肝硬化患者的经颈静脉肝内门体分流术（TIPS）与肝性脑病

Metab Brain Dis. 2025 Feb 4;40(2):117. doi: 10.1007/s11011-025-01541-w.

Short-Term Proton Pump Inhibitor Use and Hepatic Encephalopathy Risk in Patients with Decompensated Cirrhosis.失代偿期肝硬化患者短期使用质子泵抑制剂与肝性脑病风险

J Clin Med. 2019 Jul 25;8(8):1108. doi: 10.3390/jcm8081108.

Current and future pharmacological therapies for managing cirrhosis and its complications.管理肝硬化及其并发症的当前和未来药理学治疗方法。

World J Gastroenterol. 2019 Feb 28;25(8):888-908. doi: 10.3748/wjg.v25.i8.888.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Proton Pump Inhibitor Administration Triggers Encephalopathy in Cirrhotic Patients by Modulating Blood-Brain Barrier Drug Transport.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献