DeClaire Jeffrey H, Aiello Paige M, Warritay Olayinka K, Freeman Dwight C
Department of Surgery and Orthopaedic Surgery, DeClaire LaMacchia Orthopaedic Institute, Crittenton Hospital Medical Center, Rochester Hills, Michigan.
Wayne State University School of Medicine, Detroit, Michigan.
J Arthroplasty. 2017 Sep;32(9S):S268-S271. doi: 10.1016/j.arth.2017.03.062. Epub 2017 Apr 6.
We compared the effectiveness of liposomal bupivacaine to ropivacaine, each as part of multimodal pain management, in total knee arthroplasty (TKA) postoperative pain control.
This prospective, double blind study randomized 96 TKA patients into a control group (periarticular injection of ropivacaine, ketorolac, morphine, and epinephrine in saline; 100cc) or an experimental group (periarticular injection of bupivacaine, ketorolac, morphine, and epinephrine in saline; 80cc plus 1.3% liposomal bupivacaine 20cc; total injection 100cc). The postoperative use of narcotics, visual analog pain scores, hours to ambulate 100 feet, and length of hospital stay were recorded.
There was no significant difference between the two groups (control N = 49, experiment N = 47) in mean narcotic use per hour, total narcotic use during hospital stay, time to ambulate 100 feet, length of hospital stay, or visual analog score for pain postoperatively.
There is no benefit in the use of liposomal bupivacaine compared with ropivacaine for postoperative pain control in TKA.
我们比较了脂质体布比卡因与罗哌卡因作为多模式疼痛管理一部分在全膝关节置换术（TKA）术后疼痛控制中的有效性。
这项前瞻性双盲研究将96例TKA患者随机分为对照组（在盐水中关节周围注射罗哌卡因、酮咯酸、吗啡和肾上腺素；100cc）或试验组（在盐水中关节周围注射布比卡因、酮咯酸、吗啡和肾上腺素；80cc加1.3%脂质体布比卡因20cc；总注射量100cc）。记录术后麻醉剂使用情况、视觉模拟疼痛评分、行走100英尺的时间和住院时间。
两组（对照组N = 49，试验组N = 47）在每小时平均麻醉剂使用量、住院期间总麻醉剂使用量、行走100英尺的时间、住院时间或术后疼痛视觉模拟评分方面无显著差异。
在TKA术后疼痛控制中，与罗哌卡因相比，使用脂质体布比卡因并无益处。
