局部注射脂质体布比卡因与传统关节周围注射用于全膝关节置换术后疼痛控制的比较。
Liposomal bupivacaine versus traditional periarticular injection for pain control after total knee arthroplasty.
机构信息
Department of Orthopaedic Surgery, Indiana University Health Physicians, Indiana University School of Medicine, Indianapolis, Indiana.
出版信息
J Arthroplasty. 2014 Aug;29(8):1687-90. doi: 10.1016/j.arth.2014.03.034. Epub 2014 Apr 4.
The purpose of this study was to compare a novel liposomal bupivacaine to traditional peri-articular injection (PAI) in a multi-modal pain protocol for total knee arthroplasty (TKA). A retrospective cohort study compared 85 consecutive patients undergoing TKA with a traditional PAI of ropivacaine, epinephrine and morphine to 65 patients with a liposomal bupivacaine PAI. After the initial 24h, inpatient self-reported pain scores were higher in the liposomal bupivacaine group compared to the traditional PAI group (P = 0.04) and a smaller percentage (16.9%) of patients in the liposomal bupivacaine group rated their pain as "mild" compared to the traditional group (47.6%). Liposomal bupivacaine PAI provided inferior pain control compared to the less expensive traditional PAI in a multi-modal pain control program in patients undergoing TKA.
本研究旨在比较新型脂质体布比卡因与传统关节周围注射（PAI）在全膝关节置换术（TKA）多模式疼痛方案中的效果。一项回顾性队列研究比较了 85 例接受传统罗哌卡因、肾上腺素和吗啡关节周围注射的 TKA 患者与 65 例接受脂质体布比卡因 PAI 的患者。在最初的 24 小时后，脂质体布比卡因组的住院患者自我报告疼痛评分高于传统 PAI 组（P=0.04），且脂质体布比卡因组中“轻度”疼痛评分的患者比例（16.9%）低于传统组（47.6%）。在 TKA 患者的多模式疼痛控制方案中，与较便宜的传统 PAI 相比，脂质体布比卡因 PAI 提供的疼痛控制效果较差。
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