Department of Orthopaedic Surgery, Indiana University Health Physicians, Indiana University School of Medicine, Indianapolis, Indiana.
J Arthroplasty. 2014 Aug;29(8):1687-90. doi: 10.1016/j.arth.2014.03.034. Epub 2014 Apr 4.
The purpose of this study was to compare a novel liposomal bupivacaine to traditional peri-articular injection (PAI) in a multi-modal pain protocol for total knee arthroplasty (TKA). A retrospective cohort study compared 85 consecutive patients undergoing TKA with a traditional PAI of ropivacaine, epinephrine and morphine to 65 patients with a liposomal bupivacaine PAI. After the initial 24h, inpatient self-reported pain scores were higher in the liposomal bupivacaine group compared to the traditional PAI group (P = 0.04) and a smaller percentage (16.9%) of patients in the liposomal bupivacaine group rated their pain as "mild" compared to the traditional group (47.6%). Liposomal bupivacaine PAI provided inferior pain control compared to the less expensive traditional PAI in a multi-modal pain control program in patients undergoing TKA.
本研究旨在比较新型脂质体布比卡因与传统关节周围注射（PAI）在全膝关节置换术（TKA）多模式疼痛方案中的效果。一项回顾性队列研究比较了 85 例接受传统罗哌卡因、肾上腺素和吗啡关节周围注射的 TKA 患者与 65 例接受脂质体布比卡因 PAI 的患者。在最初的 24 小时后，脂质体布比卡因组的住院患者自我报告疼痛评分高于传统 PAI 组（P=0.04），且脂质体布比卡因组中“轻度”疼痛评分的患者比例（16.9%）低于传统组（47.6%）。在 TKA 患者的多模式疼痛控制方案中，与较便宜的传统 PAI 相比，脂质体布比卡因 PAI 提供的疼痛控制效果较差。
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