[Effectiveness of adrenergic transmission and mechanisms of its regulation in rats exposed to prenatal effects of ethanol].

Prenatal influence of ethanol doesn't induce the changes of 3H-NA secretion intensity from rat cerebral cortex slices, but induces an increase of coefficient of variation of 3H-NA secretion intensity. The self-facilitation and stabilization of secretion are described during study of 3H-NA secretion intensity in the series of successive depolarization of control animals slices. Prenatal influence of ethanol induces self-facilitation but destabilize 3H-NA secretion. The results show that prenatal influence of ethanol breaks of autoreceptors function which are a cause of 3H-NA secretion destabilization. The break of the higher nervous activity is followed by the break of regulation mechanisms of adrenergic transmission effectiveness which is induced by prenatal influence of ethanol.