Fuxe K, Martire M, von Euler G, Agnati L F, Hansson T, Andersson K, Gustafsson J A, Härfstrand A
Acta Physiol Scand. 1987 Jun;130(2):307-11. doi: 10.1111/j.1748-1716.1987.tb08141.x.
Subacute treatment with toluene (80-1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the beta-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of alpha 1-adrenergic ([3H]WB 4101) and alpha 2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical beta-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical beta-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity.
用甲苯（80 - 1500 ppm）进行亚急性处理会使雄性大鼠额叶皮质中β-肾上腺素能拮抗剂[3H]二氢阿普洛尔结合位点的亲和力呈剂量依赖性降低，而密度增加，与此同时，在体外评估时，该区域中α1-肾上腺素能（[3H]WB 4101）和α2-肾上腺素能（[3H]对氨基可乐定）结合位点的结合特性不受此处理的影响。因此，有人提出皮质β-肾上腺素能受体在体内对甲苯的作用特别敏感。据推测，接触低浓度甲苯后，皮质β-肾上腺素能神经传递可能会发生改变，这可能与甲苯的物理化学性质有关，从而导致膜流动性的变化。
