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[产前暴露于乙醇作用下的大鼠新皮质膜中H3-蝇蕈醇结合的特性]

[Peculiarities of H3-muscimol binding to neocortex membranes of rats exposed to the effects of ethanol in the prenatal period].

作者信息

Zhulin V V, Zabludovskiĭ A L

出版信息

Biull Eksp Biol Med. 1988 Oct;106(10):460-2.

PMID:2847833
Abstract

White rats were subjected to ethanol exposure during 5-20 days of pregnancy. 3H-muscimol binding with synaptosomal neocortex membranes yielded from two month age offsprings was studied. 3H-muscimol binding level for experimental animals was 27% more than for control ones. Possible ways of GABAergic system malformation are discussed.

摘要

将怀孕5至20天的白鼠暴露于乙醇环境中。研究了从两个月大的后代中提取的3H-蝇蕈醇与突触体新皮质膜的结合情况。实验动物的3H-蝇蕈醇结合水平比对照动物高27%。文中讨论了γ-氨基丁酸能系统畸形的可能途径。

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