[Effects of acetylcholinesterase inhibitors on the process of reinnervation of the mouse skeletal muscle].

The effect of chronic in vivo injections of anticholinesterases drugs (phosphacol, proserine) on the reinnervation of m. extensor digitorum longus were studied in adult mice after motor nerve crushing. An electrophysiological technique was used to register synaptic transmission. The chronic anticholinesterases injections were shown not to change the time of initial neuro-muscular transmission reestablishment. The potentiating effects of investigated anticholinesterase agents were poorly manifested in the early period of transmission recovery. Later in the course of reinnervation the potentiating effects become pronounced and considerably (two fold) accelerate the final recovery of normal synaptic parameters and action potential generation. Long injection of drugs is not accompanied by depression of neuromuscular transmission during reinnervation.