Engelhard D, Or R, Naparstek E, Leibovici V
Department of Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel.
Bone Marrow Transplant. 1988 Sep;3(5):517-9.
An immunocompromised patient, 6 weeks after bone marrow transplantation, developed extensive skin infection due to Trichophyton rubrum. Because she could not tolerate ketoconazole and was hypersensitive to griseofulvin, she received itraconazole with complete recovery within 30 days. This case demonstrates that itraconazole may be effective treatment for dermatophytosis, even in immunocompromised hosts, and that there is no cross-reactivity between ketoconazole and itraconazole.
一名免疫功能低下的患者在骨髓移植6周后,因红色毛癣菌感染出现广泛的皮肤感染。由于她无法耐受酮康唑且对灰黄霉素过敏,遂接受伊曲康唑治疗,30天内完全康复。该病例表明,伊曲康唑可能是治疗皮肤癣菌病的有效药物,即使在免疫功能低下的宿主中也是如此,而且酮康唑和伊曲康唑之间不存在交叉反应。