Kim S-K, Lee S-S, Choe J-Y, Park S-H, Lee H
1 Division of Rheumatology, Department of Internal Medicine, Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
2 Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.
Lupus. 2017 Dec;26(14):1540-1549. doi: 10.1177/0961203317709346. Epub 2017 May 7.
Background We assessed correlations of smoking habits and alcohol consumption with disease activity or damage in patients with systemic lupus erythematosus (SLE). Methods A total of 505 patients with SLE were enrolled in the Korean Lupus Network (KORNET) SLE registry from January 2014 to January 2016. Disease activity and organ damage were measured by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index, respectively. Multivariate logistic regression analysis was used to analyze associations with cutaneous lesions. Results There were no differences in SLEDAI-2K and SLICC/ACR damage indices according to either smoking status or alcohol consumption. More frequent cutaneous damage was observed in current alcohol drinkers compared with non-current alcohol drinkers ( p = 0.020). Cutaneous damage was significantly associated with alcohol consumption (odds ratio (OR) 4.048, 95% confidence interval (CI) 1.251-12.102, p = 0.020). Both low (1-5 glasses/week) and high (≥6 glasses/week) amounts of alcohol consumption had a significant impact on cutaneous damage compared with the absence of current alcohol consumption ( p = 0.033 and p = 0.027, respectively). Pairwise comparison of alcohol consumption and smoking status with cutaneous damage showed that only alcohol consumption was significantly associated with the presence of cutaneous damage, compared with non-current alcohol consumption and non-current smoking (OR 3.513, 95% CI 1.130-10.920, p =0.030). Conclusions Current alcohol consumption, but not smoking, might influence the development of cutaneous damage in patients with SLE.
我们评估了系统性红斑狼疮（SLE）患者的吸烟习惯和饮酒情况与疾病活动或损害之间的相关性。方法：2014年1月至2016年1月，共有505例SLE患者纳入韩国狼疮网络（KORNET）SLE登记处。分别采用2000年SLE疾病活动指数（SLEDAI-2K）和系统性红斑狼疮国际协作临床/美国风湿病学会（SLICC/ACR）损害指数来测量疾病活动和器官损害。采用多因素逻辑回归分析来分析与皮肤病变的相关性。结果：根据吸烟状况或饮酒情况，SLEDAI-2K和SLICC/ACR损害指数没有差异。与不饮酒者相比，当前饮酒者出现更频繁的皮肤损害（p = 0.020）。皮肤损害与饮酒显著相关（优势比（OR）4.048，95%置信区间（CI）1.251 - 12.102，p = 0.020）。与当前不饮酒相比，低量饮酒（1 - 5杯/周）和高量饮酒（≥6杯/周）对皮肤损害均有显著影响（分别为p = 0.033和p = 0.027）。饮酒量和吸烟状况与皮肤损害的两两比较显示，与当前不饮酒和不吸烟相比，只有饮酒与皮肤损害的存在显著相关（OR 3.513，95% CI 1.130 - 10.920，p = 0.030）。结论：当前饮酒而非吸烟可能会影响SLE患者皮肤损害的发生。
