Filiberti Rosa A, Fontana Vincenzo, De Ceglie Antonella, Blanchi Sabrina, Grossi Enzo, Della Casa Domenico, Lacchin Teresa, De Matthaeis Marina, Ignomirelli Orazio, Cappiello Roberta, Rosa Alessandra, Foti Monica, Laterza Francesco, D'Onofrio Vittorio, Iaquinto Gaetano, Conio Massimo
1Clinical Epidemiology,IRCCS AOU San Martino-IST,Largo R Benzi 10,16132 Genova,Italy.
2Gastroenterology,General Hospital,Via G Borea 56,18038 Sanremo,Imperia,Italy.
Br J Nutr. 2017 Apr;117(8):1151-1161. doi: 10.1017/S0007114517000940. Epub 2017 May 8.
Knowledge about the association between alcohol and Barrett's oesophagus and reflux oesophagitis is conflicting. In this case-control study we evaluated the role of specific alcoholic beverages (red and white wine, beer and liquors) in 339 Barrett's oesophagus and 462 oesophagitis patients compared with 619 endoscopic controls with other disorders, recruited in twelve Italian endoscopic units. Data on alcohol and other individual characteristics were obtained from structured questionnaires. No clear, monotonic significant dose-response relationship was pointed out for red wine. However, a generalised U-shaped trend of Barrett's oesophagus/oesophagitis risk due to red wine consumption particularly among current drinkers was found. Similar results were also found for white wine. Liquor/spirit consumption seemed to bring about a 1·14-2·30 risk excess, although statistically non-significant, for current Barrett's oesophagus/oesophagitis drinkers. Statistically significant decreasing dose-response relationships were found in Barrett's oesophagus for frequency and duration of beer consumption. Similar, but less clear downward tendencies were also found for oesophagitis patients. In conclusion, although often not statistically significant, our data suggested a reduced risk of Barrett's oesophagus and oesophagitis with a low/moderate intake of wine and beer consumption. A non-significant increased risk of Barrett's oesophagus/oesophagitis was observed with a higher intake of any type of heavy alcohol consumption, but no conclusion can be drawn owing to the high number of non-spirit drinkers and to the small number of drinkers at higher alcohol intake levels.
关于酒精与巴雷特食管及反流性食管炎之间关联的知识存在矛盾。在这项病例对照研究中，我们评估了特定酒精饮料（红酒、白酒、啤酒和烈酒）在339例巴雷特食管患者和462例食管炎患者中的作用，并与在意大利12个内镜科室招募的619例患有其他疾病的内镜检查对照者进行比较。酒精及其他个体特征的数据通过结构化问卷获得。未发现红酒有明确的、单调的显著剂量反应关系。然而，发现饮用红酒尤其是当前饮酒者中，巴雷特食管/食管炎风险呈现出普遍的U形趋势。白酒也有类似结果。对于当前饮用烈酒的巴雷特食管/食管炎患者，烈酒消费似乎会带来1.14至2.30倍的风险增加，尽管在统计学上不显著。在巴雷特食管患者中，发现啤酒消费频率和持续时间与剂量反应关系呈统计学显著下降。食管炎患者也有类似但不太明显的下降趋势。总之，尽管往往在统计学上不显著，但我们的数据表明，低/中度饮用葡萄酒和啤酒可降低巴雷特食管和食管炎的风险。任何类型的大量饮酒摄入量较高时，观察到巴雷特食管/食管炎风险有不显著的增加，但由于非烈酒饮用者数量众多以及高酒精摄入量水平的饮酒者数量较少，无法得出结论。
