Parrilla P, Ortiz A, Martinez de Haro L F, Aguayo J L, Ramirez P
Hospital Virgen de la Arrixaca, Universidad de Murcia, Departamento de Cirugia, Spain.
Gut. 1990 Sep;31(9):964-7. doi: 10.1136/gut.31.9.964.
A manometric study to determine the role of gastro-oesophageal reflux in Barrett's oesophagus was performed on 20 patients with Barrett's oesophagus and 53 patients with reflux oesophagitis without Barrett's oesophagus (25 with mild oesophagitis and 28 with severe oesophagitis). For the same reason, the 20 patients with Barrett's oesophagus also underwent 24 hour continuous oesophageal pH monitoring, and the results obtained were compared with those of 20 oesophagitis patients without Barrett's oesophagus (10 with mild oesophagitis and 10 with severe oesophagitis). The manometric results show that the motor changes found in the Barrett's group are specific but similar to the motor dysfunction associated with reflux oesophagitis. Motor anomalies are probably related more to the inflammatory process in the oesophageal wall than to the metaplastic changes themselves. The pH monitoring results show that while reflux in the Barrett's oesophagus patients was greater overall than in the oesophagitis group without Barrett's oesophagus, the changes are similar when the results are compared with the severe oesophagitis group. In conclusion there are other factors besides gastro-oesophageal reflux involved in the pathogenesis of Barrett's oesophagus.
对20例巴雷特食管患者以及53例无巴雷特食管的反流性食管炎患者（25例轻度食管炎患者和28例重度食管炎患者）进行了一项测压研究，以确定胃食管反流在巴雷特食管中的作用。出于同样的原因，对20例巴雷特食管患者也进行了24小时食管pH值连续监测，并将所得结果与20例无巴雷特食管的食管炎患者（10例轻度食管炎患者和10例重度食管炎患者）的结果进行比较。测压结果显示，在巴雷特组中发现的运动变化具有特异性，但与反流性食管炎相关的运动功能障碍相似。运动异常可能更多地与食管壁的炎症过程有关，而非化生改变本身。pH值监测结果显示，虽然巴雷特食管患者的反流总体上比无巴雷特食管的食管炎组更严重，但与重度食管炎组相比，结果相似。总之，除胃食管反流外，还有其他因素参与巴雷特食管的发病机制。
