流感进化：旧敌新视角。

Influenza Evolution: New Insights into an Old Foe.

机构信息

Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI 53706, USA.

Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI 53706, USA; Wisconsin National Primate Research Center, Madison, WI 53715, USA.

出版信息

Trends Microbiol. 2017 Jun;25(6):432-434. doi: 10.1016/j.tim.2017.04.003. Epub 2017 May 3.

DOI:10.1016/j.tim.2017.04.003

PMID:28478941

Abstract

Influenza viruses steadily evolve to escape detection by antibodies, necessitating vaccine updates. A new study uses a massively parallel approach, deep mutational scanning, to catalogue antibody escape mutations. This approach defines potential pathways of viral evolution, beyond those already observed in natural infections, and may help predict its future directions.

摘要

流感病毒不断进化以逃避抗体的检测，这就需要更新疫苗。一项新的研究使用大规模并行方法，深度突变扫描，对抗体逃逸突变进行编目。这种方法定义了病毒进化的潜在途径，超出了在自然感染中已经观察到的途径，并可能有助于预测其未来的方向。