慢性粒细胞白血病中的新易位：t(X;22)(p22;q11) 和 t(15;22)(q26;q11)

New translocations in chronic granulocytic leukaemia: t(X;22)(p22;q11) and t(15;22)(q26;q11).

作者信息

Hossfeld D K, Köhler S

出版信息

Br J Haematol. 1979 Feb;41(2):185-91. doi: 10.1111/j.1365-2141.1979.tb05847.x.

DOI:10.1111/j.1365-2141.1979.tb05847.x

Abstract

Two cases of Ph1-positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial cytogenetic normalization of the bone marrow during busulphan induced remission were additional remarkable features of this case. In case 2 a translocation t(15;22)(q26;q11) was found. In this case the disease was characterized by an increase of unusually small megakaryocytes, thrombocytosis, and an accelerated course.

摘要

本文报告了两例具有迄今未描述的易位的Ph1阳性慢性粒细胞白血病病例。病例1中，22号染色体长臂缺失部分易位至X染色体短臂，即t(X;22)(p22;q11)。该病例的其他显著特征包括明显的嗜碱性粒细胞增多、大多数中期细胞出现19号染色体三体，以及在白消安诱导缓解期间骨髓细胞遗传学部分正常化。病例2发现了t(15;22)(q26;q11)易位。该病例的特点是异常小的巨核细胞增多、血小板增多症以及病程加速。