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Ph1阳性慢性髓性白血病急变期的（4p+；6q-）和（12q-；Xp+）易位

Translocations (4p+; 6q-) and (12q-; Xp+) in blastic phase of a Ph1-positive chronic myeloid leukemia.

作者信息

Suciu S, Marinca E, Bornuz F, Crisan M, Petrov L, Rădulescu E

出版信息

Blut. 1984 Oct;49(4):325-30. doi: 10.1007/BF00320206.

DOI:10.1007/BF00320206
PMID:6593103
Abstract

This paper reports a 28-year-old woman with Philadelphia chromosome (Ph1)-positive chronic myeloid leukemia (CML) who developed two marrow cell lines during the blastic phase: one with the translocation (12;X) (q 11;p22) and the other with the translocation (4;6) (p 16;q 25). The literature on involvement of chromosomes 12 and X in translocations and the appearance of 6 q- aberration in CML is summarized. The relationship between the 6 q-aberration and the blast cells with lymphoid appearance in the plastic phase of CML is discussed.

摘要

本文报道了一名28岁的费城染色体（Ph1）阳性慢性髓性白血病（CML）女性患者，其在急变期出现了两种骨髓细胞系：一种带有易位（12；X）（q11；p22），另一种带有易位（4；6）（p16；q25）。本文总结了关于12号和X号染色体参与易位以及CML中6q-异常出现的文献。讨论了CML急变期6q-异常与具有淋巴样外观的原始细胞之间的关系。

相似文献

1
Translocations (4p+; 6q-) and (12q-; Xp+) in blastic phase of a Ph1-positive chronic myeloid leukemia.Ph1阳性慢性髓性白血病急变期的（4p+；6q-）和（12q-；Xp+）易位
Blut. 1984 Oct;49(4):325-30. doi: 10.1007/BF00320206.
2
Variant Ph1 translocations in CML and their incidence, including two cases with sequential lymphoid and myeloid crises.慢性粒细胞白血病中的Ph1易位变异及其发生率，包括两例先后发生淋巴细胞危象和髓细胞危象的病例。
Cancer Genet Cytogenet. 1982 Mar;5(3):187-201. doi: 10.1016/0165-4608(82)90025-5.
3
Complex translocation t(3;9;22) and paracentric inversion of chromosome 3 in blastic crisis of chronic myeloid leukemia.
Cancer Genet Cytogenet. 1986 Feb 15;20(3-4):305-9. doi: 10.1016/0165-4608(86)90088-9.
4
Chromosomes and causation of human cancer and leukemia. XXV. Significance of the Ph1 (including unusual translocations) in various acute leukemias.
Cancer. 1977 Sep;40(3):1149-60. doi: 10.1002/1097-0142(197709)40:3<1149::aid-cncr2820400326>3.0.co;2-k.
5
Cytogenetic heterogeneity in blast crisis (BC) of chronic myelogenous leukemia (CML).
Blut. 1985 Nov;51(5):361-3. doi: 10.1007/BF00320047.
6
Involvement of chromosomes 8, 9, 19 and 22 in PH1 positive and PH1 negative chronic myelocytic leukemia in the chronic or blastic stage.
Acta Med Scand. 1974 Nov;196(5):355-60. doi: 10.1111/j.0954-6820.1974.tb01024.x.
7
Chromosome abnormalities in chronic myeloid leukemia in children.儿童慢性髓性白血病中的染色体异常
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"Masked" philadelphia chromosome (Ph1) due to an unusual translocation.因异常易位导致的“隐匿性”费城染色体（Ph1）
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Coexistence of cells with unmasked and masked Ph1 in a case of chronic myeloid leukemia in blastic phase.
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Promyelocytic blast crisis of chronic myelocytic leukemia with both t(9;22) and t(15;17) in M3 cells.
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引用本文的文献

1
Cytogenetic heterogeneity in blast crisis (BC) of chronic myelogenous leukemia (CML).
Blut. 1985 Nov;51(5):361-3. doi: 10.1007/BF00320047.

本文引用的文献

1
Chromosomal, morphological and clinical correlations in blastic crisis of chronic myeloid leukaemia: a study of 69 cases.
Scand J Haematol. 1982 Feb;28(2):103-17. doi: 10.1111/j.1600-0609.1982.tb00502.x.
2
Chromosomal abnormalities in acute lymphoblastic leukemia: structural and numerical changes in 234 cases.
Cancer Genet Cytogenet. 1981 Oct;4(2):101-10. doi: 10.1016/0165-4608(81)90076-5.
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"Masked" philadelphia chromosome (Ph1) due to an unusual translocation.因异常易位导致的“隐匿性”费城染色体（Ph1）
Cancer Genet Cytogenet. 1981 Apr;3(3):227-32. doi: 10.1016/0165-4608(81)90088-1.
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New types of unusual and complex Philadelphia chromosome (Ph1) translocations in chronic myeloid leukemia.
Cancer Genet Cytogenet. 1981 Jan;3(1):19-31. doi: 10.1016/0165-4608(81)90052-2.
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Chromosomes and causation of human cancer and leukemia: XL. The Ph1 and other translocations in CML.
Cancer. 1980 Nov 15;46(10):2221-6. doi: 10.1002/1097-0142(19801115)46:10<2221::aid-cncr2820461019>3.0.co;2-8.
6
The treatment of terminal metamorphosis of chronic granulocytic leukaemia with corticosteroids and vincristine.用皮质类固醇和长春新碱治疗慢性粒细胞白血病终末期变态反应。
Acta Haematol. 1973;50(1):1-8. doi: 10.1159/000208322.
7
A rapid banding technique for human chromosomes.一种用于人类染色体的快速显带技术。
Lancet. 1971 Oct 30;2(7731):971-2. doi: 10.1016/s0140-6736(71)90287-x.
8
Antisera to acute lymphoblastic leukemia cells.抗急性淋巴细胞白血病细胞血清。
Clin Immunol Immunopathol. 1975 May;4(1):67-84. doi: 10.1016/0090-1229(75)90041-0.
9
Terminal deoxynucleotidyl transferase activities in human blood leukocytes and lymphoblast cell lines: high levels in lymphoblast cell lines and in blast cells of some patients with chronic myelogenous leukemia in acute phase.人血白细胞和淋巴母细胞系中的末端脱氧核苷酸转移酶活性：在淋巴母细胞系以及部分急性期慢性粒细胞白血病患者的原始细胞中活性较高。
Blood. 1976 Jan;47(1):11-20.
10
The pathogenesis and clinical patterns of blastic crisis of chronic myeloid leukemia.
Semin Oncol. 1976 Sep;3(3):289-96.