Sut C, Tariket S, Cognasse F, Garraud O
Université de Lyon, GIMAP-EA3064, 42023 Saint-Étienne, France; Établissement français du sang Rhône-Alpes-Auvergne, 42023 Saint-Étienne, France.
Université de Lyon, GIMAP-EA3064, 42023 Saint-Étienne, France; Institut national de la transfusion sanguine, 75015 Paris, France.
Transfus Clin Biol. 2017 Jun;24(2):87-91. doi: 10.1016/j.tracli.2017.04.002. Epub 2017 May 4.
The introduction of allogeneic cells is not a natural process, even if the transfusion is therapeutic and - when no alternative exists, as is often the case - essential. Transfusion of cellular products creates some level of danger sensed by recipients. Danger may manifest itself clinically or biologically, in which case we are dealing with recipient adverse reactions. Platelet concentrate transfusion in particular may be responsible for notable adverse reactions. Some appear to be inevitable, while others are tied to recipient factors: either health or genetic characteristics. The authors' research is specifically focused on platelet storage lesion and stress factors, and the means of controlling them to ensure greater recipient tolerance.
异体细胞的输入并非自然过程，即便这种输血具有治疗作用，而且在通常没有其他选择的情况下是必不可少的。细胞制品的输血会给受血者带来一定程度的危险。危险可能在临床或生物学上表现出来，在这种情况下我们面对的是受血者的不良反应。尤其是血小板浓缩物输血可能会引发显著的不良反应。有些不良反应似乎不可避免，而其他一些则与受血者因素有关：健康状况或遗传特征。作者的研究特别关注血小板储存损伤和应激因素，以及控制这些因素以确保受血者有更高耐受性的方法。
