蝶枕联合早融合对颅缝早闭综合征患者的面中部发育不良和阻塞性睡眠呼吸暂停的影响。
The effect of early fusion of the spheno-occipital synchondrosis on midface hypoplasia and obstructive sleep apnea in patients with Crouzon syndrome.
机构信息
Department of Plastic, Reconstructive and Hand Surgery, Dutch Craniofacial Centre, Rotterdam, The Netherlands.
Department of Plastic, Reconstructive and Hand Surgery, Dutch Craniofacial Centre, Rotterdam, The Netherlands.
出版信息
J Craniomaxillofac Surg. 2017 Jul;45(7):1069-1073. doi: 10.1016/j.jcms.2017.03.024. Epub 2017 Apr 8.
INTRODUCTION
The investigators hypothesized that patients with Crouzon syndrome and premature fusion of the spheno-occipital synchondrosis (SOS) more often have, or have more severe midface hypoplasia and obstructive sleep apnea (OSA).
METHODS
A prospective cohort study was performed among patients with Crouzon syndrome to analyze SOS closure, midface hypoplasia represented by the sella-nasion angle (SNA) and OSA.
RESULTS
Forty patients were included in whom the OSA-prevalence was 65%. Kaplan Meier analyses suggest a trend towards earlier closure of synchondrosis in patients with OSA (p = 0.066). The mean SNA was 74.7°. There was a positive effect of age on the SNA (p = 0.020). There was no difference in SNA for patients with an open SOS as compared to patients with a closed SOS after correction for age.
CONCLUSIONS
The longitudinal data are suggestive of a trend towards earlier fusion of the SOS in patients with Crouzon syndrome and OSA as compared to patients with Crouzon syndrome without OSA. Although the SNA increases with age, our results suggest that this increase in independent closure of the SOS.
简介
研究者假设颅缝早闭并伴蝶枕联合融合的 Crouzon 综合征患者更易发生或存在更严重的面中部发育不全和阻塞性睡眠呼吸暂停（OSA）。
方法
前瞻性队列研究纳入 Crouzon 综合征患者，分析蝶枕联合融合情况、以蝶鞍鼻根点角（SNA）表示的面中部发育不全和 OSA。
结果
共纳入 40 例患者，其中 OSA 发生率为 65%。Kaplan-Meier 分析提示 OSA 患者蝶枕联合更早融合（p=0.066）。平均 SNA 为 74.7°。SNA 与年龄呈正相关（p=0.020）。校正年龄后，未闭蝶枕联合患者与已闭蝶枕联合患者的 SNA 无差异。
结论
纵向数据提示，与无 OSA 的 Crouzon 综合征患者相比，伴 OSA 的 Crouzon 综合征患者的蝶枕联合融合更早。尽管 SNA 随年龄增长而增加，但我们的结果提示 SOS 独立融合的这种增加。
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