BACKGROUND

has been used by many tribes to treat variety of diseases and known to have many essential secondary metabolites. To the best of our knowledge, it is the first comparative analysis of total fatty acid (FA) composition and α-amylase inhibition activity of .

OBJECTIVE

The present study is carried out to explore the antihyperglycemic activity and FA contents of all parts of .

MATERIAL AND METHOD

Fruits, leaves, stems, and roots part of have been extracted in ethanol. Simultaneously, all plant parts have been extracted in hexane with Soxhlet extraction. Ethanolic extracts have been evaluated for antihyperglycemic activity and hexane extract have been analyzed for FA identification.

RESULT

The present study indicated that ethanolic extract of fruit and leaves have shown significant α-amylase inhibitory activity with IC value of 92.86 ± 0.89 and 98.09 ± 0.69 μg/mL, respectively. FA composition of all the parts of was analyzed by GC/MS. Nineteen FAs have been identified in all parts of in which palmitic acid, oleic acid, linolenic acid, and linoleic acid were major FAs.

CONCLUSION

The study indicates that has significant potential to inhibit α-amylase enzyme and it is a rich source of essential FAs.

SUMMARY

has significant antidiabetic activity and will be beneficial for diabetic patients to reduce the starch breakdown and helps in reduction of postprandial hyperglycemia. It can be used in the formulation of diabetic drugs. is rich source of essential FAs and may be used as a nutraceutical.Ethanol extract of fruits and leaves of are showed the maximum α-amylase inhibition when compared with standard drug acarbose. DM: Diabetes Mellitus, FA: Fatty Acid, FFAs: Free Fatty Acids, FAME: Fatty Acid Methyl Ester, IC50: Inhibitor Concentration, GC-MS: Gas Chromatography- Mass Spectrophotometer.