Department of Genetics and Stanley S Scott Cancer Center, School of Medicine, LSU Health Science Center, New Orleans, LA 70112, USA.
J Ethnopharmacol. 2010 Jan 8;127(1):98-102. doi: 10.1016/j.jep.2009.09.042. Epub 2009 Sep 30.
Leucas cephalotes (Roth.) Spreng. (Laminaceae) is an ayurvedic traditional medicinal plant used in India, Nepal and Pakistan to treat several ailments including diabetes.
The aim of the present study is to investigate the antidiabetic, antihyperlipaemic and antioxidant activities of Leucas cephalotes for its purported use in diabetes.
The ethanol extract of leaves of Leucas cephalotes was administered (150, 300 and 450 mg kg(-1)bw) to diabetes induced (IDDM and NIDDM) rats and carbohydrate, lipid, antioxidant, urea and creatinine profiles were assessed.
All the three doses of extract decreased plasma glucose and lipid profiles and, improved the antioxidant status of both types of diabetic rats. The extract administration improved hepatic glycogen content and hexokinase activity, decreased glucose-6-phosphatase activity, blood urea, creatinine contents and decreased lipid peroxidation in diabetic rats. Of the three doses used, 450 mg kg(-1)bw dose was found to be more potent in its effects comparable to those of glibenclamide and metformin.
Leucas cephalotes regulates both carbohydrate and lipid metabolism and, improves body antioxidant defense systems in both types of diabetes.
Leucas cephalotes（Roth.）Spreng.（唇形科）是一种印度、尼泊尔和巴基斯坦的阿育吠陀传统药用植物，用于治疗多种疾病，包括糖尿病。
本研究旨在研究 Leucas cephalotes 的抗糖尿病、抗高脂血症和抗氧化活性，因为它据称可用于治疗糖尿病。
给予糖尿病诱导（IDDM 和 NIDDM）大鼠 Leucas cephalotes 叶的乙醇提取物（150、300 和 450 mg kg(-1)bw），并评估碳水化合物、脂质、抗氧化剂、尿素和肌酐谱。
提取物的所有三个剂量均降低了两种糖尿病大鼠的血糖和脂质谱，并改善了其抗氧化状态。提取物的给药改善了肝糖原含量和己糖激酶活性，降低了葡萄糖-6-磷酸酶活性、血糖、肌酐含量和糖尿病大鼠的脂质过氧化。在使用的三个剂量中，450 mg kg(-1)bw 剂量的效果更为明显，与格列本脲和二甲双胍相当。
Leucas cephalotes 调节碳水化合物和脂质代谢，并改善两种类型糖尿病的机体抗氧化防御系统。
