Bano Farah, Baber Muhammad, Ali Amjad, Shah Ziaullah, Muhammad Syed Aun
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
Atta-ur-Rehman School of Applied Biosciences (ASAB), National University of Science and Technology, Islamabad, Pakistan.
Pharmacogn Mag. 2017 Jan;13(Suppl 1):S33-S36. doi: 10.4103/0973-1296.203985. Epub 2017 Apr 7.
Iron nanoparticles (FeNPs) have got many biomedical and health applications because of biocompatible and nontoxic nature to humans.
To synthesize the FeNPs using natural sources.
In this study, simple and economical procedure was adopted for FeNPs synthesis. Sesame seeds were processed to obtain seed extract as a biological material for FeNPs production. FeNPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopic.
The average diameter of these FeNPs was 99 nm. These nanoparticles showed significant anti-typhoid activity (30 mm zone of inhibition) as compared to ciprofloxacin (32 mm) as standard. Furthermore, alpha-amylase inhibitory assay also showed moderate antidiabetic activity with more than 50% inhibition.
This study would be helpful in understanding of nanoparticles synthesis from natural sources and ultimately will be used as potential alternative therapeutic agents.
Iron nanoparticles (FeNPs) were synthesized by seedsFeNPs were characterized by scanning electron microscope with average diameter of 99 nmThese FeNPs are effective against , a causative agent of typhoidThese FeNPs can be used as antidiabetic agent. FeNPs: Iron Nano Particles; SEM: Scanning Electron Microscopy; MIC: Minimum Inhibitory Concentration; : .
由于铁纳米颗粒（FeNPs）对人类具有生物相容性且无毒，因此在许多生物医学和健康领域都有应用。
利用天然来源合成FeNPs。
本研究采用简单且经济的方法合成FeNPs。将芝麻籽进行处理以获得种子提取物，作为生产FeNPs的生物材料。通过傅里叶变换红外光谱、X射线衍射和扫描电子显微镜对FeNPs进行表征。
这些FeNPs的平均直径为99nm。与作为标准的环丙沙星（抑菌圈为32mm）相比，这些纳米颗粒显示出显著的抗伤寒活性（抑菌圈为30mm）。此外，α-淀粉酶抑制试验也显示出中度的抗糖尿病活性，抑制率超过50%。
本研究将有助于理解从天然来源合成纳米颗粒，最终可作为潜在的替代治疗剂。
通过种子合成了FeNPs，用扫描电子显微镜对FeNPs进行表征，其平均直径为99nm，这些FeNPs对伤寒的病原体有效，这些FeNPs可用作抗糖尿病剂。FeNPs：铁纳米颗粒；SEM：扫描电子显微镜；MIC：最低抑菌浓度； ： 。
