Cordes Thekla, Metallo Christian M
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Curr Opin Chem Eng. 2016 Nov;14:72-81. doi: 10.1016/j.coche.2016.08.019. Epub 2016 Sep 10.
Metabolism coordinates the conversion of available nutrients toward energy, biosynthetic intermediates, and signaling molecules to mediate virtually all biological functions. Dysregulation of metabolic pathways contributes to many diseases, so a detailed understanding of human metabolism has significant therapeutic implications. Over the last decade major technological advances in the areas of analytical chemistry, computational estimation of intracellular fluxes, and biological engineering have improved our ability to observe and engineer metabolic pathways. These approaches are reminiscent of the design, operation, and control of industrial chemical plants. Immune cells have emerged as an intriguing system in which metabolism influences diverse biological functions. Application of metabolic flux analysis and related approaches to macrophages and T cells offers great therapeutic opportunities to biochemical engineers.
新陈代谢协调可用营养物质向能量、生物合成中间体和信号分子的转化，以介导几乎所有的生物学功能。代谢途径的失调会导致许多疾病，因此详细了解人类新陈代谢具有重要的治疗意义。在过去十年中，分析化学、细胞内通量的计算估计和生物工程领域的重大技术进步提高了我们观察和设计代谢途径的能力。这些方法让人联想到工业化工厂的设计、操作和控制。免疫细胞已成为一个有趣的系统，其中新陈代谢影响多种生物学功能。将代谢通量分析及相关方法应用于巨噬细胞和T细胞，为生物化学工程师提供了巨大的治疗机会。
