McKay Michael J, Rady Kirsty L, McKay Thomas A
Department of Medicine, University of Sydney, Camperdown, NSW, Australia.
Canberra Hospital and Australian National University, Canberra, ACT, Australia.
Ann Transl Med. 2017 Apr;5(7):162. doi: 10.21037/atm.2017.03.85.
Hairy cell leukaemia (HCL) is rare, accounting for only 2% of leukaemias. An even more infrequent variant has been described, HCL-V. The clinicopathologic features of these two entities overlap significantly, although they differ in a number of aspects, including demographics and immunophenotype. In this report, we present the case of a man with HCL-V diagnosed 12 years previously, who is currently haematologically stable with an unusual complication of joint pain due to extensive bony expansion secondary to leukaemic infiltration, and atypical skeletal imaging. His painful joint disease responded dramatically to radiotherapy.
毛细胞白血病（HCL）较为罕见，仅占白血病的2%。一种更为罕见的变异型已被描述，即变异型毛细胞白血病（HCL-V）。这两种疾病的临床病理特征有显著重叠，尽管它们在许多方面存在差异，包括人口统计学特征和免疫表型。在本报告中，我们介绍了一例12年前被诊断为HCL-V的男性病例，他目前血液学稳定，但因白血病浸润继发广泛骨质增生和非典型骨骼影像学表现而出现关节疼痛这一不寻常的并发症。他的疼痛性关节疾病对放疗反应显著。
