茜草科植物和豆科植物对东莨菪碱诱导的记忆缺失小鼠的认知增强特性
COGNITIVE-ENHANCING PROPERTIES OF (RUBIACEAE) AND (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE.
作者信息
O Elufioye Taiwo, Halimah A Hameed
机构信息
Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Nigeria.
出版信息
Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):136-141. doi: 10.21010/ajtcam.v14i3.14. eCollection 2017.
BACKGROUND
Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of (L) Rubiaceae and (DC) ex. K Heyne in scopolamine induced amnesic animals.
MATERIALS AND METHODS
The anti-amnesic activity of the ethyl acetate extracts of and at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg were assessed in scopolamine induced amnesic mice using Morris water maze test model. Effect of the extracts on the histology of the hippocampus was also evaluated.
RESULTS
The ethyl acetate extract of and ameliorated scopolamine induced memory deficit in the animals under study. There was no effect of the extract on the histology of the hippocampus. However, there was an increase in the density of cells in the hippocampus of treated group as compared to the untreated.
CONCLUSION
and showed considerable enhancement of cognition in scopolamine induced amnesic mice.
背景
非洲传统医学从业者利用各种植物成功治疗了与衰老相关的认知障碍。本研究评估了茜草科的（L）和茜草科（DC）ex. K Heyne在东莨菪碱诱导的记忆缺失动物中的认知增强潜力。
材料与方法
使用莫里斯水迷宫测试模型，在东莨菪碱诱导的记忆缺失小鼠中评估了茜草科和茜草科剂量为4mg/kg、6mg/kg和8mg/kg的乙酸乙酯提取物的抗遗忘活性。还评估了提取物对海马组织学的影响。
结果
茜草科和茜草科的乙酸乙酯提取物改善了所研究动物中东莨菪碱诱导的记忆缺陷。提取物对海马组织学没有影响。然而，与未治疗组相比，治疗组海马中的细胞密度增加。
结论
茜草科和茜草科在东莨菪碱诱导的记忆缺失小鼠中显示出相当大的认知增强作用。
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