复合微乳凝胶的制备与性质
PREPARATION AND PROPERTIES OF COMPOUND MICROEMULSION GEL.
作者信息
Chen Jing, He Yanping, Gao Ting, Zhang Licheng, Zhao Yuna
机构信息
Department of Pharmaceutics, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
出版信息
Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):274-279. doi: 10.21010/ajtcam.v14i3.28. eCollection 2017.
BACKGROUND
Compound oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable and inconvenient to use. The aim of this study was to prepare a compound microemulsion gel for transdermal delivery system and evaluate its characteristics.
MATERIALS AND METHODS
Based on the solubility of Shikonin, the active component of and the results of phase studies, adequate ratio of each component in microemulsion was determined. The optimized microemulsion gel was prepared using Carbomer 940. The gels were characterized in terms of appearance, preliminary stability test and the content of Shikonin in the compound microemulsion gel with HPLC analysis.
RESULTS
The optimized conditions for preparing microemulsion were Tween-80, glycerin, isopropyl myristate (IPM) with the ratio of 6:3:2. The optimal microemulsion gel was obtained with Carbomer 940 (1.0%).
CONCLUSION
The prepared compound microemulsion gel showed good stability over time. It is more convenience in application than the previous used formulations.
背景
复方油在临床上长期用于治疗烧伤和烫伤。然而，它不稳定且使用不便。本研究的目的是制备一种用于透皮给药系统的复方微乳凝胶并评估其特性。
材料与方法
根据紫草素（其活性成分）的溶解度以及相研究结果，确定微乳中各成分的合适比例。使用卡波姆940制备优化后的微乳凝胶。通过外观、初步稳定性测试以及用高效液相色谱法分析复方微乳凝胶中紫草素的含量对凝胶进行表征。
结果
制备微乳的优化条件为吐温-80、甘油、肉豆蔻酸异丙酯（IPM），比例为6:3:2。用1.0%的卡波姆940获得了最佳微乳凝胶。
结论
所制备的复方微乳凝胶随时间显示出良好的稳定性。与先前使用的制剂相比，其应用更方便。
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