Napoli Eleonora, Borlongan Cesar V
Department of Molecular Biosciences, University of California Davis, Davis, California, USA.
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA.
Stem Cells. 2017 Jun;35(6):1443-1445. doi: 10.1002/stem.2636.
This commentary highlights the major findings and future research directions arising from the recent publication by Zuo and colleagues in Stem Cells 2017 (in press). Here, we discuss the novel observations that transplanted human neural stem cells can induce endogenous brain repair by specifically stimulating a host of regenerative processes in the neurogenic niche (i.e., subventricular zone [SVZ]) in an animal model of Parkinson's disease. That the identified therapeutic proteomes, neurotrophic factors, and anti-inflammatory cytokines in the SVZ may facilitate brain regeneration and behavioral recovery open a new venue of research for our understanding of the pathology and treatment of Parkinson's disease. Stem Cells 2017;35:1443-1445.
本评论重点介绍了左及其同事近期发表于《干细胞》2017年刊（即将出版）的主要研究发现及未来研究方向。在此，我们讨论了一些新的观察结果，即在帕金森病动物模型中，移植的人类神经干细胞可通过特异性刺激神经源性微环境（即脑室下区[SVZ]）中的一系列再生过程来诱导内源性脑修复。脑室下区中已确定的治疗性蛋白质组、神经营养因子和抗炎细胞因子可能促进脑再生和行为恢复，这为我们理解帕金森病的病理学和治疗开辟了一个新的研究领域。《干细胞》2017年；35:1443 - 1445。
