Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson's disease.
作者信息
Borlongan Cesar V
机构信息
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612
出版信息
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6322-6324. doi: 10.1073/pnas.1807276115. Epub 2018 May 30.
Abstract
摘要
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本文引用的文献
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Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.将α-突触核蛋白原纤维注入小鼠胃肠道会通过迷走神经在脑干中诱导出类似路易小体的聚集物。
Mol Neurodegener. 2018 May 11;13(1):21. doi: 10.1186/s13024-018-0257-5.
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Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.细胞微环境赋予了α-突触核蛋白病中独特的病理性α-突触核蛋白菌株。
Nature. 2018 May;557(7706):558-563. doi: 10.1038/s41586-018-0104-4. Epub 2018 May 9.
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Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.可溶性环氧化物水解酶在帕金森病的发病机制中起关键作用。
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5815-E5823. doi: 10.1073/pnas.1802179115. Epub 2018 May 7.
4
Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.可溶性环氧化物水解酶抑制减轻局灶性脑缺血再灌注损伤。
Sci Rep. 2018 Mar 27;8(1):5279. doi: 10.1038/s41598-018-23504-1.
5
Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology.在大鼠和非人类灵长类动物的肠神经系统中诱导 alpha-突触核蛋白病理会导致胃肠道动力障碍和短暂的中枢神经系统病理。
Neurobiol Dis. 2018 Apr;112:106-118. doi: 10.1016/j.nbd.2018.01.008. Epub 2018 Jan 16.
6
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.α-突触核蛋白在帕金森病SNCA三倍体诱导多能干细胞衍生的神经元中引发未折叠蛋白反应。
Hum Mol Genet. 2017 Nov 15;26(22):4441-4450. doi: 10.1093/hmg/ddx331.
7
Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota.餐后降低可溶性环氧化物水解酶活性：胰岛素和肠道菌群的作用。
J Nutr Biochem. 2017 Nov;49:8-14. doi: 10.1016/j.jnutbio.2017.07.006. Epub 2017 Jul 21.
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A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.神经元α-突触核蛋白在胃肠道免疫中的作用。
J Innate Immun. 2017;9(5):456-463. doi: 10.1159/000477990. Epub 2017 Jun 27.
9
Cell Therapy in Parkinson's Disease: Host Brain Repair Machinery Gets a Boost From Stem Cell Grafts.帕金森病的细胞疗法：干细胞移植助力宿主脑修复机制
Stem Cells. 2017 Jun;35(6):1443-1445. doi: 10.1002/stem.2636.
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Parkinson disease.帕金森病。
Nat Rev Dis Primers. 2017 Mar 23;3:17013. doi: 10.1038/nrdp.2017.13.
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