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Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease.脑脊髓液脂肪酸在葡萄糖脑苷脂酶相关帕金森病中的变化。
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Fatty diet, mitochondria and Parkinson's disease.高脂肪饮食、线粒体与帕金森病。
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Management of the aging risk factor for Parkinson's disease.帕金森病衰老风险因素的管理。
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Development of a Highly Sensitive Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer.开发一种高灵敏度的酶联免疫吸附测定法，通过结合多克隆捕获抗体和纳米抗体示踪剂来检测小鼠可溶性环氧化物水解酶。
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A Gutsy Move for Cell-Based Regenerative Medicine in Parkinson's Disease: Targeting the Gut Microbiome to Sequester Inflammation and Neurotoxicity.针对帕金森病的基于细胞的再生医学的大胆举措：靶向肠道微生物组以隔离炎症和神经毒性。
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Gutting the brain of inflammation: A key role of gut microbiome in human umbilical cord blood plasma therapy in Parkinson's disease model.清除大脑炎症：肠道微生物组在帕金森病模型中人类脐带血血浆治疗中的关键作用。
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Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders.可溶性环氧化物水解酶在精神和神经疾病中多不饱和脂肪酸代谢中的作用
Front Pharmacol. 2019 Jan 30;10:36. doi: 10.3389/fphar.2019.00036. eCollection 2019.
9
Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders.从 humble beginnings 到宏伟目标：小分子可溶环氧化物水解酶抑制剂治疗中枢神经系统疾病。
Prog Neurobiol. 2019 Jan;172:23-39. doi: 10.1016/j.pneurobio.2018.11.001. Epub 2018 Nov 14.
10
May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells.愿原力与你同在：将健康的线粒体从干细胞转移到中风细胞。
J Cereb Blood Flow Metab. 2019 Feb;39(2):367-370. doi: 10.1177/0271678X18811277. Epub 2018 Oct 30.

本文引用的文献

1
Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.将α-突触核蛋白原纤维注入小鼠胃肠道会通过迷走神经在脑干中诱导出类似路易小体的聚集物。
Mol Neurodegener. 2018 May 11;13(1):21. doi: 10.1186/s13024-018-0257-5.
2
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.细胞微环境赋予了α-突触核蛋白病中独特的病理性α-突触核蛋白菌株。
Nature. 2018 May;557(7706):558-563. doi: 10.1038/s41586-018-0104-4. Epub 2018 May 9.
3
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.可溶性环氧化物水解酶在帕金森病的发病机制中起关键作用。
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5815-E5823. doi: 10.1073/pnas.1802179115. Epub 2018 May 7.
4
Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.可溶性环氧化物水解酶抑制减轻局灶性脑缺血再灌注损伤。
Sci Rep. 2018 Mar 27;8(1):5279. doi: 10.1038/s41598-018-23504-1.
5
Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology.在大鼠和非人类灵长类动物的肠神经系统中诱导 alpha-突触核蛋白病理会导致胃肠道动力障碍和短暂的中枢神经系统病理。
Neurobiol Dis. 2018 Apr;112:106-118. doi: 10.1016/j.nbd.2018.01.008. Epub 2018 Jan 16.
6
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.α-突触核蛋白在帕金森病SNCA三倍体诱导多能干细胞衍生的神经元中引发未折叠蛋白反应。
Hum Mol Genet. 2017 Nov 15;26(22):4441-4450. doi: 10.1093/hmg/ddx331.
7
Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota.餐后降低可溶性环氧化物水解酶活性：胰岛素和肠道菌群的作用。
J Nutr Biochem. 2017 Nov;49:8-14. doi: 10.1016/j.jnutbio.2017.07.006. Epub 2017 Jul 21.
8
A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.神经元α-突触核蛋白在胃肠道免疫中的作用。
J Innate Immun. 2017;9(5):456-463. doi: 10.1159/000477990. Epub 2017 Jun 27.
9
Cell Therapy in Parkinson's Disease: Host Brain Repair Machinery Gets a Boost From Stem Cell Grafts.帕金森病的细胞疗法：干细胞移植助力宿主脑修复机制
Stem Cells. 2017 Jun;35(6):1443-1445. doi: 10.1002/stem.2636.
10
Parkinson disease.帕金森病。
Nat Rev Dis Primers. 2017 Mar 23;3:17013. doi: 10.1038/nrdp.2017.13.

Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson's disease.

作者信息

Borlongan Cesar V

机构信息

Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612

出版信息

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6322-6324. doi: 10.1073/pnas.1807276115. Epub 2018 May 30.

DOI:10.1073/pnas.1807276115
PMID:29848628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6016787/
Abstract
摘要