血清阴性血液制品可预防骨髓移植后原发性巨细胞病毒感染。
Seronegative blood products prevent primary cytomegalovirus infection after bone marrow transplantation.
作者信息
Mackinnon S, Burnett A K, Crawford R J, Cameron S, Leask B G, Sommerville R G
机构信息
Department of Haematology, Glasgow Royal Infirmary, Scotland.
出版信息
J Clin Pathol. 1988 Sep;41(9):948-50. doi: 10.1136/jcp.41.9.948.
Seventy one patients underwent bone marrow transplantation for aplastic anaemia or haematological malignancy, 39 as allografts and 32 as autografts. All patients who were seronegative to cytomegalovirus received blood product support exclusively from seronegative community blood donors; seropositive patients received unscreened products. In no patients was there any attempt to reduce cytomegalovirus (CMV) infection by giving prophylaxis with immunoglobulin, and granulocyte transfusions were not given. The incidence of cytomegalovirus infection in the seronegative recipients (22 allograft, 15 autograft) was 0%; in the seropositive recipients 16 (63%) in allografts and 17 (18%) in autografts. These results suggest that provision of exclusively seronegative blood products is an important contribution for seronegative transplant recipients, but make little impact in autologous transplantation where the incidence of infection is low.
71例患者因再生障碍性贫血或血液系统恶性肿瘤接受了骨髓移植，其中39例为同种异体移植，32例为自体移植。所有对巨细胞病毒血清学阴性的患者仅接受来自血清学阴性的社区献血者的血液制品支持；血清学阳性的患者接受未筛查的制品。没有任何患者试图通过给予免疫球蛋白预防来降低巨细胞病毒（CMV）感染，也未给予粒细胞输注。血清学阴性受者（22例同种异体移植，15例自体移植）中巨细胞病毒感染的发生率为0%；血清学阳性受者中，同种异体移植为16例（63%），自体移植为17例（18%）。这些结果表明，仅提供血清学阴性的血液制品对血清学阴性的移植受者有重要作用，但对感染发生率较低的自体移植影响不大。
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