中国急性呼吸道感染住院儿童中WU多瘤病毒的分子流行病学研究
Molecular epidemiology of WU polyomavirus in hospitalized children with acute respiratory tract infection in China.
作者信息
Zhu Teng, Lu Qing-Bin, Zhang Shu-Yan, Wo Ying, Zhuang Lu, Zhang Pan-He, Zhang Xiao-Ai, Wei Wei, Liu Wei
机构信息
Graduate School of Anhui Medical University, Hefei 230032, PR China.
State Key Laboratory of Pathogen & Biosecurity, Beijing Institute of Microbiology & Epidemiology, Beijing 100071, PR China.
出版信息
Future Microbiol. 2017 May;12:481-489. doi: 10.2217/fmb-2016-0144. Epub 2017 May 8.
AIM
To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China.
MATERIALS & METHODS: A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract infections. WUPyV was detected using real-time PCR and complete genome was sequenced for randomly selected positive nasopharyngeal aspirate.
RESULTS
Altogether 122 (7.5%) of 1617 children found to be infected with WUPyV and 88 (72.1%) were coinfected with other viruses during 2012-2015. The phylogenetic analysis showed that 14 strains from our study formed two new clusters (Id and IIIc) within the Branch I and Branch III, respectively.
CONCLUSION
WUPyV is persistently circulating in China. Surveillance on WUPyV infection in wider areas and long persistence is warranted.
目的
探讨中国急性呼吸道感染儿童患者中华盛顿大学多瘤病毒（WUPyV）感染的分子流行病学及临床特征。
材料与方法
开展实验室监测以招募急性呼吸道感染儿童患者。采用实时荧光定量聚合酶链反应检测WUPyV，并对随机选取的阳性鼻咽抽吸物进行全基因组测序。
结果
2012年至2015年期间，1617名儿童中共有122名（7.5%）被发现感染WUPyV，其中88名（72.1%）同时感染了其他病毒。系统发育分析表明，我们研究中的14个毒株分别在分支I和分支III内形成了两个新的簇（Id和IIIc）。
结论
WUPyV在中国持续传播。有必要在更广泛地区对WUPyV感染进行监测并长期持续监测。
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