D' Agostin Flavia, de Michieli Paola, Negro Corrado
University of Trieste, Trieste, Italy (Clinical Unit of Occupational Medicine, Department of Medicine, Surgery and Health Sciences).
Int J Occup Med Environ Health. 2017 May 8;30(3):419-431. doi: 10.13075/ijomeh.1896.00890. Epub 2017 Mar 20.
Malignant mesothelioma is closely associated to asbestos exposure. One such exposure may occur through contact with occupationally exposed household members and their belongings. This study examines the features of pleural mesothelioma attributable only to asbestos brought home by another family member.
The data sources were 1063 mesothelioma cases diagnosed between 1995 and 2014, from the Friuli Venezia Giulia Mesothelioma Register. In all cases the diagnosis of mesothelioma was based on the pathology report. Exposure information and demographic data were acquired by an occupational medical standardized questionnaire/interview.
Household-exposure mesothelioma cases included 33 women and 2 men. Relationships were: wives (N = 22), daughters (N = 9), sons (N = 2), and mothers (N = 2). Asbestos exposure in the workers predominantly occurred in shipyards. Out of the 35 pleural cases, 19 were epithelial, 9 biphasic, 3 sarcomatoid, and 4 not specified. The mean age at diagnosis was 77 years old. The mean latency was 59 years, with wives having a significant shorter latency than offspring. Latency was not significantly related to morphology and asbestosis. The overall mean survival was 16 months (median 11 months) but treatment was beneficial (mean 16 months vs. 7 months). Biphasic/sarcomatoid histology and presence of asbestosis were associated with a decreased survival, although not with statistical significance.
Our data confirms that household exposure increases the risk for pleural mesothelioma amongst women with no history of occupational asbestos exposure. This is an ongoing problem in many countries, as well as in Italy, where the evaluation of a framework for the compensation of these cases is under debate. Int J Occup Med Environ Health 2017;30(3):419-431.
恶性间皮瘤与接触石棉密切相关。一种此类接触可能通过与职业性接触石棉的家庭成员及其物品接触而发生。本研究调查仅因另一名家庭成员带回家的石棉而导致的胸膜间皮瘤的特征。
数据来源为1995年至2014年间在弗留利-威尼斯朱利亚间皮瘤登记处诊断的1063例间皮瘤病例。所有间皮瘤病例的诊断均基于病理报告。接触信息和人口统计学数据通过职业医学标准化问卷/访谈获取。
家庭接触性间皮瘤病例包括33名女性和2名男性。关系分别为：妻子（N = 22）、女儿（N = 9）、儿子（N = 2）和母亲（N = 2）。工人中的石棉接触主要发生在造船厂。在35例胸膜病例中，19例为上皮型，9例为双向型，3例为肉瘤样型，4例未明确分型。诊断时的平均年龄为77岁。平均潜伏期为59年，妻子的潜伏期明显短于后代。潜伏期与形态学和石棉沉着病无显著相关性。总体平均生存期为16个月（中位数为11个月），但治疗有益（平均16个月对7个月）。双向型/肉瘤样组织学和石棉沉着病的存在与生存期缩短相关，尽管无统计学意义。
我们的数据证实，家庭接触会增加无职业性石棉接触史女性患胸膜间皮瘤的风险。在许多国家以及意大利，这都是一个持续存在的问题，在意大利，关于这些病例赔偿框架的评估正在讨论中。《国际职业医学与环境卫生杂志》2017年；30(3):419 - 431。
