采用直方图分析的血管屏蔽灌注磁共振成像可提高胶质瘤分级的诊断准确性。
Vessel-Masked Perfusion Magnetic Resonance Imaging With Histogram Analysis Improves Diagnostic Accuracy for the Grading of Glioma.
作者信息
Arisawa Atsuko, Watanabe Yoshiyuki, Tanaka Hisashi, Takahashi Hiroto, Matsuo Chisato, Fujiwara Takuya, Fujimoto Yasunori, Yamamoto Kouji, Tomiyama Noriyuki
机构信息
From the Departments of *Diagnostic and Interventional Radiology, †Neurosurgery, and ‡Clinical Epidemiology and Biostatistics, Osaka University Graduate School of Medicine, Osaka, Japan.
出版信息
J Comput Assist Tomogr. 2017 Nov/Dec;41(6):910-915. doi: 10.1097/RCT.0000000000000614.
OBJECTIVE
Dynamic susceptibility contrast magnetic resonance imaging is widely used to assess glioma grade; histogram analyses are used for precise tumor perfusion evaluations. We evaluated the effect of vessel contamination in normalized cerebral blood volume (nCBV) to differentiate high- and low-grade gliomas.
METHODS
Thirty-four patients with gliomas underwent dynamic susceptibility contrast magnetic resonance imaging. Both traditional and vessel-masked nCBV maps were constructed. Histogram analyses of whole tumors and statistical comparisons were performed to compare traditional and vessel-masked images.
RESULTS
Mean values of all the histogram metrics were lower in vessel-masked images than in traditional images. Receiver operating characteristic curve analyses for every histogram metric showed a higher area under the curve for vessel-masked images than for traditional images. The integrated discrimination improvement showed that the vessel-masked images were superior to the traditional images significantly for predicting the glioma grading.
CONCLUSIONS
Vessel-masked nCBV maps can prevent overestimations of CBV measurements and can improve diagnostic accuracy for glioma grading.
目的
动态磁敏感对比增强磁共振成像被广泛用于评估胶质瘤分级；直方图分析用于精确的肿瘤灌注评估。我们评估了正常脑血容量（nCBV）中血管污染对鉴别高级别和低级别胶质瘤的影响。
方法
34例胶质瘤患者接受了动态磁敏感对比增强磁共振成像检查。构建了传统的和血管掩码的nCBV图。对整个肿瘤进行直方图分析并进行统计比较，以比较传统图像和血管掩码图像。
结果
血管掩码图像中所有直方图指标的平均值均低于传统图像。对每个直方图指标进行的受试者工作特征曲线分析显示，血管掩码图像的曲线下面积高于传统图像。综合鉴别改善表明，血管掩码图像在预测胶质瘤分级方面明显优于传统图像。
结论
血管掩码nCBV图可防止CBV测量值的高估，并可提高胶质瘤分级的诊断准确性。
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