Case Western Reserve University School of Medicine, Cleveland, Ohio; Central Brain Tumor Registry of the United States, Hinsdale, Illinois; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Neuro Oncol. 2017 Oct 19;19(11):1553-1564. doi: 10.1093/neuonc/nox091.
Previous reports have shown that overall incidence of malignant brain and other central nervous system (CNS) tumors varied significantly by country. The aim of this study was to estimate histology-specific incidence rates by global region and assess incidence variation by histology and age.
Using data from the Central Brain Tumor Registry of the United States (CBTRUS) and the International Agency for Research on Cancer's (IARC) Cancer Incidence in Five Continents X (including over 300 cancer registries), we calculated the age-adjusted incidence rates (AAIR) per 100000 person-years and 95% CIs for brain and other CNS tumors overall and by age groups and histology.
There were significant differences in incidence by region. Overall incidence of malignant brain tumors per 100000 person-years in the US was 5.74 (95% CI = 5.71-5.78). Incidence was lowest in Southeast Asia (AAIR = 2.55, 95% CI = 2.44-2.66), India (AAIR = 2.85, 95% CI = 2.78-2.93), and East Asia (AAIR = 3.07, 95% CI = 3.02-3.12). Incidence was highest in Northern Europe (AAIR = 6.59, 95% CI = 6.52-6.66) and Canada (AAIR = 6.53, 95% CI = 6.41-6.66). Astrocytic tumors showed the broadest variation in incidence regionally across the globe.
Brain and other CNS tumors are a significant source of cancer-related morbidity and mortality worldwide. Regional differences in incidence may provide clues toward genetic or environmental causes as well as a foundation for broadening knowledge of their epidemiology. Gaining a comprehensive understanding of the epidemiology of malignant brain tumors globally is critical to researchers, public health officials, disease interest groups, and clinicians and contributes to collaborative efforts in future research.
先前的报告表明，全球各国恶性脑肿瘤和其他中枢神经系统（CNS）肿瘤的总体发病率差异显著。本研究的目的是估计全球各区域的组织学特异性发病率，并评估组织学和年龄对发病率变化的影响。
我们利用美国中央脑肿瘤登记处（CBTRUS）和国际癌症研究机构（IARC）癌症发病率在五个大陆（X）的数据（包括 300 多个癌症登记处），计算了脑和其他 CNS 肿瘤的年龄标准化发病率（AAIR），每 100000 人年和 95%置信区间（CI），并按年龄组和组织学进行分组。
不同区域的发病率存在显著差异。美国恶性脑肿瘤的总发病率为每 100000 人年 5.74（95%CI=5.71-5.78）。东南亚（AAIR=2.55，95%CI=2.44-2.66）、印度（AAIR=2.85，95%CI=2.78-2.93）和东亚（AAIR=3.07，95%CI=3.02-3.12）的发病率最低。北欧（AAIR=6.59，95%CI=6.52-6.66）和加拿大（AAIR=6.53，95%CI=6.41-6.66）的发病率最高。星形细胞瘤在全球范围内的发病率区域差异最大。
脑和其他 CNS 肿瘤是全球癌症相关发病率和死亡率的重要来源。发病率的区域差异可能为遗传或环境原因提供线索，并为扩大对其流行病学的认识奠定基础。全面了解全球恶性脑肿瘤的流行病学情况对研究人员、公共卫生官员、疾病利益团体以及临床医生都至关重要，有助于促进未来研究的合作努力。
