Kaji R, Sumner A J
Department of Neurology, University of Pennsylvania, Philadelphia.
Neurology. 1988 Dec;38(12):1884-7. doi: 10.1212/wnl.38.12.1884.
We studied the effect of systemically administered 4-aminopyridine in a model of CNS demyelination. In five rats with demyelination, slowed conduction velocity through the lesion was partially reversed at dose levels of 5.6 to 7.2 mg/kg. All rats developed convulsion at this dosage, and impaired conduction of high-frequency impulses was unchanged. These findings suggest certain limitations of 4-aminopyridine as a therapeutic agent.
我们在中枢神经系统脱髓鞘模型中研究了全身给药4-氨基吡啶的效果。在五只脱髓鞘大鼠中，当剂量为5.6至7.2mg/kg时，通过损伤部位的传导速度减慢得到了部分逆转。所有大鼠在该剂量下均出现惊厥，且高频冲动的传导受损情况未改变。这些发现表明4-氨基吡啶作为一种治疗药物存在一定局限性。
