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用于治疗结核分枝杆菌感染的新药。

New drugs for the treatment of Mycobacterium tuberculosis infection.

作者信息

AlMatar Manaf, AlMandeal Husam, Var Işıl, Kayar Begüm, Köksal Fatih

机构信息

Department of Biotechnology, Institute of Natural and Applied Sciences (Fen Bilimleri Enstitüsü), Cukurova University, Adana, Turkey.

Universitätsklinikum des Saarlandes, Gebäude 90, Kirrberger Straße, D-66421, Homburg, Germany.

出版信息

Biomed Pharmacother. 2017 Jul;91:546-558. doi: 10.1016/j.biopha.2017.04.105. Epub 2017 May 5.

Abstract

Tuberculosis presents a grave challenge to health, globally instigating 1.5 million mortalities each year. Following the breakthrough of first-line anti-TB medication, the number of mortalities reduced greatly; nonetheless, the swift appearance of tuberculosis which was drug-resistant, as well as the capability of the bacterium to survive and stay dormant are a considerable problem for public health. In order to address this issue, several novel possible candidates for tuberculosis therapy have been subjected to clinical trials of late. The novel antimycobacterial agents are acquired from different categories of medications, operate through a range of action systems, and are at various phases of advancement. We therefore talk about the present methods of treating tuberculosis and novel anti-TB agents with their action method, in order to advance awareness of these new compounds and medications.

摘要

结核病对全球健康构成了严峻挑战,每年导致150万人死亡。随着一线抗结核药物的突破,死亡人数大幅减少;然而,耐药结核病的迅速出现以及细菌的存活和潜伏能力对公共卫生来说是一个相当大的问题。为了解决这个问题,近年来几种新型的结核病治疗候选药物已经进入临床试验阶段。这些新型抗分枝杆菌药物来自不同类别的药物,通过一系列作用机制发挥作用,并且处于不同的研发阶段。因此,我们将讨论目前治疗结核病的方法以及新型抗结核药物及其作用方式,以提高对这些新化合物和药物的认识。

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