Botton Jérémie, Kadawathagedara Manik, de Lauzon-Guillain Blandine
Inserm, UMR1153 epidemiology and biostatistics Sorbonne Paris Cité center (CRESS), Team "early origin of the child's health and development" (ORCHAD), Paris Descartes university, Paris, France; Faculty of pharmacy, université Paris-Sud, université Paris-Saclay, 92296 Châtenay-Malabry, France.
Inserm, UMR1153 epidemiology and biostatistics Sorbonne Paris Cité center (CRESS), Team "early origin of the child's health and development" (ORCHAD), Paris Descartes university, Paris, France.
Ann Endocrinol (Paris). 2017 Jun;78(2):108-111. doi: 10.1016/j.ando.2017.04.009. Epub 2017 May 5.
According to the "environmental obesogen hypothesis", early-life (including in utero) exposure to endocrine disrupting chemicals (EDCs) may disturb the mechanisms involved in adipogenesis or energy storage, and thus may increase the susceptibility to overweight and obesity. Animal models have shown that exposure to several of these chemicals could induce adipogenesis and mechanisms have been described. Epidemiological studies are crucial to know whether this effect could also be observed in humans. We aimed at summarizing the literature in epidemiology on the relationship between EDCs exposure and child's growth. Overall, epidemiological studies suggest that pre- and/or early postnatal exposure to some EDCs may increase the risk of overweight or obesity during childhood. In that review, we present some limitations of these studies, mainly in exposure assessment, that currently prevent to conclude about causality. Recent advances in epidemiology should bring further knowledge.
根据“环境致肥胖假说”，生命早期（包括子宫内）接触内分泌干扰化学物质（EDCs）可能会扰乱脂肪生成或能量储存所涉及的机制，从而可能增加超重和肥胖的易感性。动物模型表明，接触其中几种化学物质可诱导脂肪生成，且相关机制已得到描述。流行病学研究对于了解这种效应是否也能在人类中观察到至关重要。我们旨在总结流行病学文献中关于EDCs暴露与儿童生长之间的关系。总体而言，流行病学研究表明，产前和/或产后早期接触某些EDCs可能会增加儿童期超重或肥胖的风险。在该综述中，我们提出了这些研究的一些局限性，主要在于暴露评估方面，这些局限性目前妨碍了对因果关系的推断。流行病学的最新进展应能带来更多知识。
