Institut Curie, Paris Sciences et Lettres (PSL) Research University, 26 rue d'Ulm, 75248 Paris, France; Génétique et Biologie du Développement, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité U934, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 3215, Institut Curie, 26 rue d'Ulm, 75248 Paris, France.
Institut Curie, Paris Sciences et Lettres (PSL) Research University, 26 rue d'Ulm, 75248 Paris, France; Génétique et Biologie du Développement, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité U934, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 3215, Institut Curie, 26 rue d'Ulm, 75248 Paris, France.
Trends Biochem Sci. 2017 Jul;42(7):531-542. doi: 10.1016/j.tibs.2017.04.003. Epub 2017 May 5.
Polycomb repressive complex 2 (PRC2) and its histone H3 lysine-27 methylation activity are crucial for multicellular development by virtue of their role in maintaining transcriptional repression patterns. The recruitment and enzymatic activity of PRC2 are controlled by a series of intricate mechanisms whose molecular details have been emerging at a rapid pace. Recent studies have uncovered intriguing modes of PRC2 regulation by facultative PRC2 subunits, PRC1, and specific features of the chromatin environment. Together, these findings have produced a rich and fast-evolving picture of the biochemical signals that govern PRC2 function, with many exciting questions still remaining.
多梳抑制复合物 2（PRC2）及其组蛋白 H3 赖氨酸-27 甲基化活性对于多细胞发育至关重要，因为它们在维持转录抑制模式方面发挥作用。PRC2 的募集和酶活性受到一系列复杂机制的控制，其分子细节正在迅速出现。最近的研究揭示了 PRC2 调节因子、PRC1 和染色质环境特定特征的 PRC2 调节的有趣模式。这些发现共同描绘了控制 PRC2 功能的生化信号的丰富而快速发展的图景，仍有许多令人兴奋的问题有待解决。
