Faculty of Health Sciences, University of Macau, Macau, China.
Cancer Centre, Faculty of Health Sciences, University of Macau, Macau, China.
Epigenetics Chromatin. 2020 Oct 31;13(1):47. doi: 10.1186/s13072-020-00369-1.
Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, PRC2 facultative subunits and post-translational modifications (PTMs) of PRC2 subunits. Overall, these findings have provided insight into the biochemical signals directing PRC2 function, although many mysteries remain.
多梳抑制复合物 2（PRC2）是一种染色质修饰酶，可催化组蛋白 H3 赖氨酸 27（H3K27me1/2/3）的甲基化。该复合物维持基因转录抑制，并在维持细胞身份和正常生物体发育方面发挥重要作用。PRC2 的活性，包括其基因组靶向和催化活性，受各种信号的控制。最近的研究表明，这些信号涉及顺式染色质特征、PRC2 可选亚基和 PRC2 亚基的翻译后修饰（PTMs）。总的来说，这些发现为指导 PRC2 功能的生化信号提供了深入了解，尽管仍有许多谜团存在。
