[柯萨奇A13病毒和柯萨奇B4病毒在小鼠实验性感染中的致糖尿病特性]

[Diabetogenic properties of Coxsackie A13 and Coxsackie B4 viruses in experimental infection in mice].

作者信息

Bocharov E F, Shorin Iu P, Solodovnikova I A, Kazarian L S, Seliatitskaia V G

出版信息

Vopr Virusol. 1988 Jul-Aug;33(4):469-74.

Abstract

Studies of diabetogenic properties of Coxsackie A13 and B4 viruses in mice sensitive to diabetes (males, DBA line) and resistant (males and females F1(CBA X C57BL/6), females DBA/2 using in the latter case the subdiabetogenic doses of alloxan revealed in the infected animals biochemical changes manifested by reduction of glucose tolerance and disorders in the synthesis of immunoreactive insulin. Most marked changes were observed in males of DBA/2 line infected with Coxsackie B4 virus and in males F1 (CBA X C57BL/6) and females DBA/2 infected with Coxsackie A14 virus. With Coxsackie A13 virus such data have been obtained for the first time.

摘要

在对糖尿病敏感的小鼠（雄性，DBA品系）和抗性小鼠（雄性和雌性F1（CBA×C57BL/6），雌性DBA/2，后者使用小剂量致糖尿病剂量的四氧嘧啶）中，研究柯萨奇A13和B4病毒的致糖尿病特性。结果显示，受感染动物出现生化变化，表现为葡萄糖耐量降低和免疫反应性胰岛素合成紊乱。在感染柯萨奇B4病毒的DBA/2品系雄性小鼠以及感染柯萨奇A14病毒的F1（CBA×C57BL/6）雄性小鼠和DBA/2雌性小鼠中观察到最明显的变化。对于柯萨奇A13病毒，首次获得了此类数据。