感染柯萨奇病毒的小鼠实验性糖尿病
[Experimental diabetes in mice infected with Coxsackie viruses].
作者信息
Bocharov E F, Shorin Iu P, Solodovnikova I A, Kazarian L S, Seliatitskaia V G
出版信息
Biull Eksp Biol Med. 1987 Feb;103(2):163-6.
PMID:3028528
Abstract
The influence of Coxsackie B4 and AI3 viruses on the pancreas of mice (resistant and susceptible to diabetes) was studied. Glucose intolerance and changes in the synthesis of immunoreactive insulin were detected in all the treated groups of animals. Biochemical changes were more prominent in male DBA/2 mice, infected with Coxsackie B4 virus, in FI (CBA X C57Bl/6) hybrids and in female DBA/2 mice infected with Coxsackie AI3 virus and alloxan.
摘要
研究了柯萨奇B4病毒和AI3病毒对（抗糖尿病和易患糖尿病的）小鼠胰腺的影响。在所有接受治疗的动物组中均检测到葡萄糖不耐受以及免疫反应性胰岛素合成的变化。在感染柯萨奇B4病毒的雄性DBA/2小鼠、FI（CBA×C57Bl/6）杂交种以及感染柯萨奇AI3病毒和四氧嘧啶的雌性DBA/2小鼠中，生化变化更为显著。
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