柯萨奇病毒B4可在非人灵长类动物中引发短暂性糖尿病。

Coxsackie virus B4 produces transient diabetes in nonhuman primates.

作者信息

Yoon J W, London W T, Curfman B L, Brown R L, Notkins A L

出版信息

Diabetes. 1986 Jun;35(6):712-6. doi: 10.2337/diab.35.6.712.

DOI:10.2337/diab.35.6.712

Abstract

Cynomolgus, rhesus, and Cebus monkeys failed to show glucose tolerance or insulin secretion abnormalities after infection with encephalomyocarditis virus or Coxsackie virus B4. Patas monkeys also showed no abnormalities after infection with encephalomyocarditis virus. However, patas monkeys infected with Coxsackie virus B4 or treated first with a subdiabetogenic dose of streptozocin and then infected sequentially with Coxsackie viruses B4 and B3 showed transient elevation of glucose tolerance tests, depressed insulin secretion, and glucose in the urine. Our experiments in nonhuman primates support earlier studies in mice and humans that under certain circumstances, Coxsackie viruses can cause abnormalities in glucose homeostasis.

摘要

食蟹猴、恒河猴和松鼠猴在感染脑心肌炎病毒或柯萨奇病毒B4后，未表现出葡萄糖耐量或胰岛素分泌异常。豚尾猴感染脑心肌炎病毒后也未表现出异常。然而，感染柯萨奇病毒B4或先用亚糖尿病剂量的链脲佐菌素治疗，然后依次感染柯萨奇病毒B4和B3的豚尾猴，葡萄糖耐量试验出现短暂升高、胰岛素分泌降低且出现尿糖。我们在非人类灵长类动物身上进行的实验支持了早期在小鼠和人类身上进行的研究，即在某些情况下，柯萨奇病毒可导致葡萄糖稳态异常。