Molokwu Jennifer C, Penaranda Eribeth, Lopez David S, Dwivedi Alok, Dodoo Christopher, Shokar Navkiran
Department of Family and Community Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas.
Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas.
Cancer Epidemiol Biomarkers Prev. 2017 Aug;26(8):1321-1327. doi: 10.1158/1055-9965.EPI-17-0129. Epub 2017 May 8.
An estimated 33% of adults in the United States have metabolic syndrome (MetS), which has been associated with an increased risk for various cancer types. Theories of synergism among components of MetS that increase cancer risk via chronic inflammation and oxidative stress have been proposed. We hypothesize that men and women with MetS may have compromised immunological response resulting in increased risk for persistent human papillomavirus (HPV) infection. The goal of this study is to determine the association of MetS with HPV types 6, 11, 16, and 18 and to explore variation of these associations by gender using data from a national survey. We conducted a retrospective cross-sectional study using data from the National Health and Nutrition Examination Survey. Thirty-two percent of the population sampled met the criteria for MetS (16% men and 33% women). Nineteen percent tested positive for HPV (6, 11, 16, and 18). Prevalence of HPV infection was estimated at 13% for men and 30% for females. MetS was found to be significantly associated with increased risk of HPV6, 11, 16, or 18 in the entire cohort [RR = 1.24; 95% confidence interval (CI), 1.03-1.48] and in females (RR = 1.26; 95% CI, 1.02-1.56). Although the adjusted risk of HPV+ve status was found to be 21% higher in men with MetS compared with those without, this difference did not attain statistical significance. We observed a significant association between metabolic syndrome and HPV sero-positivity among the overall population and among females. Although not significant, a similar effect was noted in men. Further prospective studies are needed to better understand this relationship. To the best of our knowledge, this is the first study evaluating the impact of metabolic syndrome on HPV positivity in both males and females. .
据估计，美国33%的成年人患有代谢综合征（MetS），该综合征与多种癌症类型的风险增加有关。有人提出了代谢综合征各组成部分之间通过慢性炎症和氧化应激增加癌症风险的协同作用理论。我们假设患有代谢综合征的男性和女性可能存在免疫反应受损的情况，从而导致持续性人乳头瘤病毒（HPV）感染风险增加。本研究的目的是利用一项全国性调查的数据，确定代谢综合征与6、11、16和18型HPV的关联，并按性别探讨这些关联的差异。我们使用来自美国国家健康和营养检查调查的数据进行了一项回顾性横断面研究。抽样人群中有32%符合代谢综合征的标准（男性为16%，女性为33%）。19%的人HPV检测呈阳性（6、11、16和18型）。估计男性HPV感染率为13%，女性为30%。在整个队列中，发现代谢综合征与HPV6、11、16或18型感染风险增加显著相关[相对风险（RR）=1.24；95%置信区间（CI），1.03 - 1.48]，在女性中也是如此（RR = 1.26；95%CI，1.02 - 1.56）。尽管发现患有代谢综合征的男性HPV阳性状态的调整风险比未患代谢综合征的男性高21%，但这种差异未达到统计学显著性。我们观察到在总体人群和女性中，代谢综合征与HPV血清阳性之间存在显著关联。虽然在男性中不显著，但也注意到了类似的效应。需要进一步的前瞻性研究来更好地理解这种关系。据我们所知，这是第一项评估代谢综合征对男性和女性HPV阳性影响的研究。
