Itoh K, Kyakuno M, Sakai H, Kokado Y, Sagawa S, Shin T
Department of Urology, Osaka Prefectural Hospital.
Hinyokika Kiyo. 1988 Aug;34(8):1443-7.
A 67-year-old man presented with asymptomatic gross hematuria. Cystoscopy and radiographic studies revealed a large tumor on the left lateral wall of the urinary bladder. Also, computer tomographic (CT) scan of the pelvic cavity showed metastasis to the left external iliac node. The light microscopic appearance of cold punch biopsy specimens for the tumor was closely akin to small cell carcinoma of the lung. Ultrastructurally, the tumor cells exhibited small numbers of neurosecretory granules in the cytoplasm. After surgical treatment, the patient was treated with combined chemotherapy using cis-diamminedichloroplatinum (CDDP) and etoposide. On CT scan, a remarkable remission was shown to have been induced at the metastatic site after three cycles of the therapy. Though the morphology of bladder tumors has not received very much attention, this report emphasizes that detailed pathological examination is of therapeutic importance.
一名67岁男性因无症状肉眼血尿就诊。膀胱镜检查和影像学检查发现膀胱左侧壁有一个大肿瘤。此外，盆腔计算机断层扫描（CT）显示左髂外淋巴结转移。肿瘤冷切活检标本的光镜表现与肺小细胞癌极为相似。超微结构上，肿瘤细胞胞质内可见少量神经分泌颗粒。手术治疗后，患者接受了顺二氯二氨铂（CDDP）和依托泊苷联合化疗。CT扫描显示，三个周期治疗后转移部位出现明显缓解。尽管膀胱肿瘤的形态学尚未受到太多关注，但本报告强调详细的病理检查具有治疗重要性。
