Combination chemotherapy for acute myelocytic leukemia during pregnancy: three case reports.

The cases of three patients with acute myelocytic leukemia presenting during the second trimester of pregnancy are summarized. All three patients were treated with combination chemotherapy. One patient, while in remission, underwent elective abortion of an apparently normal fetus. This patient is alive and free of disease 2 years after bone marrow transplantation. Each of the other two patients was spontaneously delivered of a premature infant. Transient bone marrow suppression occurred in one of these infants. Both children were small for their gestational age. One patient died 9 days after her infant was delivered and the other survived for 13 months.